A follow-up question about part of Diana's answer: "The importance of recLOH's is that, despite causing a count difference of more than one, they represent one mutation event (i.e., a genetic distance of one). If you count each numerical difference as a single-step mutation, you will over-estimate the genetic distance between individuals. " My understanding is that the FTDNATiP calculator algorithm takes this into account. Is that so? Or, am I mistaken? -ralpht_/)