I have my mothers family way back into the 1600s and there may have been some 1st cousins getting married in the early 1700s but not later. We have more than our fair share of ADHD (that's how Uncle Buzzy got his name), depression and substance abuse. We used to call it alcoholism but the last generation stepped up their use and branched out. So far no bi-polar but I have friends and some shirttail relatives with it in their family and I can't think of anything more devastating when it is uncontrolled. My heart goes out to families to have to deal with it. We have a string of real renegades that I think came down our Vance line. I've heard other say the same thing.