Hello, David-- My SC Wise family apparently is from Marion Co. James Wise [1781 SC-1858 LA] is the farthest back we know. It could be his dad was named Ambrose Wise. [One of James' sons was as well.] James Wise m Permelia Miller who was b 1780 SC and d 1845 LA. Permelia Miller Wise had a brother named John Walter Miller. He was b Oct 1807 in SC [what co. I don't know] and d Jan 1878 Wayne Co. MS. He married Samantha Anne Payne ca 1824 SC [no co. known]. Their desc. were in LA, AR, and TX as well. The Wises went to Copiah Co. MS then to Claiborne Parish LA. There were many marraiges with the LAMBRIGHT family with roots in SC and George Lambright m Dorcas Shuler possibly of Orangeburgh. [Haven't found her name in the Orangeburgh site listings yet, however.] Are any of these names in your databases? Thanks...Ann Harper Bonner in Springhill, LA [my paternal gm was a Wise]