The Isaac Wise from Monongalia Co. in my database was born about 1839. His parents were John Wise (born 1816) and Henrietta Thomas. Perhaps the Isaac Born 1818 in Morgantown was a brother. I believe that John Wise also had brothers Thomas (b. about 1821, Battelle District, Monongalia, VA; d. Oct 23 1890) and Alfred (b. about 1814). Their parents were George Wise (b. 1773) and Jane King.