"No issue" means no children. On the "removed" definition, this is from Reunion's book: "A first coursin once removed is a term we could describe either the child of your first cousin or the child of your great-aunt. They distinguish between the two when noting people in the program. For example, the child of your first cousin is called a cousin in the descendancy.....your 1C1R*. To understand the difference, it may help to think of this person as a descendant of a full cousin. The child of your great-aunt is a cousin in the ascendancy...your 1C1R. In this case, the person is actually an ancestor of one of your full cousins...your second cousin." Hopes this helps, peg