In the late 1600s and up to about 1750, the American Indians were "good neighbors" and got along excedingly well with the Penn family and the Quakers. From some accounts, they practically worshipped Wm Penn. The Indian tribes left the Cumberland Valley area about 1728 to move westward. But it was not until the treaty of October, 1736, when the Cumberland Valley was "officially" traded to the Penn proprietaries. Even before this date, the Penn family had established the Pexton Manor , 7551 acres where current-day Camp Hill, Lemoyne, New Cumberland, etc.now exist. This Manor had one purpose only: it would be held open for the Indians in case they wanted to return from western PA and Ohio. A major reason, at least one often overlooked, for being eager to "plant" the Scots and the Germans west of the Susquehanna was to prevent the state of Maryland from claiming this land. Some research into the "Cresap Border War" (can be found in Google) will give some details of this activity.