I had a college paper to write on Epidemics and found the following information: Hope it help. 1657 - Boston -- Measles 1687 - Boston -- Measles 1690 - New York --Yellow Fever 1713 - Boston -- Measles 1729 - Boston -- Measles 1732-3 - Worldwide -- Influenza 1738 - South Carolina -- Smallpox 1739-40 - Boston -- Measles 1747 - CT,NY,PA,SC -- Measles 1759 - North America [areas inhabited by white people] -- Measles 1761 - North America and West Indies -- Influenza 1772 - North America -- Measles 1775 - North America [especially hard in Northeast] epidemic -- Unknown 1775-6 - Worldwide [one of the worst epidemics] -- Influenza 1783 - Dover, DE ["extremely fatal"] -- Bilious Disorder 1784 - New Bern, NC (Craven Co) -- Yellow Fever 1788 - Philadelphia and New York -- Measles 1793 - Vermont [a "putrid" fever] and -- Influenza 1793 - Virginia [killed 500 in 5 counties in 4 weeks] -- Influenza 1793 - Philadelphia [one of the worst epidemics] -- Yellow Fever 1793 - Harrisburg, PA [many unexplained deaths] -- Unknown 1793 - Middletown, PA [many mysterious deaths] -- Unknown 1794 - Philadelphia, PA -- Yellow Fever 1796-7 - Philadelphia, PA -- Yellow Fever 1798 - Philadelphia, PA [one of the worst] -- Yellow Fever 1798 - New Bern, NC (Craven Co) -- Yellow Fever 1803 - New York -- Yellow Fever 1820-3 - Nationwide [starts-Schuylkill River and spreads] -- "Fever" 1831-2 - Nationwide [brought by English emigrants] -- Asiatic Cholera 1832 - New York City and other major cities -- Cholera 1837 - Philadelphia -- Typhus 1841 - Nationwide [especially severe in the south] -- Yellow Fever 1847 - New Orleans -- Yellow Fever 1847-8 - Worldwide -- Influenza 1848-9 - North America -- Cholera 1850 - Nationwide -- Yellow Fever 1850-1 - North America -- Influenza 1852 - Nationwide [New Orleans-8,000 die in summer] -- Yellow Fever 1855 - Nationwide [many parts] -- Yellow Fever 1857-9 - Worldwide [one of the greated epidemics] -- Influenza 1860-1 - Pennsylvania -- Smallpox 1865-73 - Philadelphia, New York, Boston, New Orleans -- Smallpox 1865-73 - Baltimore, Memphis, Washington DC -- Cholera [A series of recurring epidemics of: Typhus, Typhoid, Scarlet Fever, Yellow Fever] 1873-5 - North America and Europe -- Influenza 1878 - New Orleans [last great epidemic] -- Yellow Fever 1885 - Plymouth, PA -- Typhoid 1886 - Jacksonville, FL -- Yellow Fever 1918 - Worldwide [high point year] -- Influenza More people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps Finally, these specific instances of Cholera were mentioned: 1833 Columbus, OH 1834 New York City 1849 New York 1851 Coles Co., Illinois, The Great Plains, and Missouri Judy Neu Henrietta, NY