I do have version 16 on my Vista machine. It does run okay but do run the patch that is offered after you have loaded the program on your computer. Hope this helps. Johnny L Lowery 903-631-5678 cell 877-494-9105 fax LOWERY & Related Spelling DNA Project Administrator _http://www.familytreedna.com/public/LOWERYandRelatedSpellingsDNAProject/index .aspx_ (http://www.familytreedna.com/(gbdmr1ffuwxztp45mlrwor2i)/public/LOWERYandRelatedSpellingsDNAProject/index.aspx) **************Get the Moviefone Toolbar. Showtimes, theaters, movie news & more!(http://pr.atwola.com/promoclk/100000075x1212774565x1200812037/aol?redir=htt p://toolbar.aol.com/moviefone/download.html?ncid=emlcntusdown00000001)