YEAR(S) REGION, AREA, CITY or STATE DISEASE 1657 Boston Measles 1687 Boston Measles 1690 New York Yellow Fever 1713 Boston Measles 1729 Boston Measles 1732-1733 Worldwide Influenza 1738 South Carolina Smallpox 1739-1740 Boston Measles 1747 Connecticut, New York, Pennsylvania, South Carolina Smallpox 1759 North America Measles 1761 North America and West Indies Influenza 1772 North America Measles 1775 North America (especially in North East) Unknown 1775-1776 Worldwide Influenza 1783 Dover, Delaware (was extremely fatal) Bilious Disorder 1788 Philadelphia and New York Measles 1793 Vermont (a "putrid" fever) and Influenza 1793 Virginia (killed 500 in 5 counties in 4 weeks) Influenza 1793 Philadelphia Yellow Fever 1793 Harrisburg, PA (many unexplained deaths) Unknown 1793 Middletown, Pennsylvania (many mysterious deaths) Unknown 1794 Philadelphia, Pennsylvania Yellow Fever 1796-1797 Philadelphia, Pennsylvania Yellow Fever 1798 Philadelphia, Pennsylvania (one of the worst) Yellow Fever 1803 New York Yellow Fever 1820-1823 Nationwide (started at Schuylkill River & spread) "Fever" 1831-1832 Nationwide (brought in by English Immigrants) Asiatic Cholera 1832 New York and other major cities Cholera 1833 Columbus, Ohio Cholera 1833-34 Kentucky Cholera 1834 New York City, New York Cholera 1837 Philadelphia Typhus 1841 Nationwide (especially severe in the South) Yellow Fever 1847 New Orleans Yellow Fever 1847-1848 Worldwide Influenza 1848-1849 North America Cholera 1849 New York Cholera 1850 Nationwide Yellow Fever 1850-1851 North America Influenza 1851 Coles County, Illinois, The Great Plains, and Missouri Cholera 1852 Nationwide (New Orleans 8,000 died that summer) Yellow Fever 1855 Nationwide Yellow Fever 1857-1859 Worldwide (one of the largest epidemics) Influenza 1860-1861 Pennsylvania Smallpox 1865-1873 Philadelphia, New York, Boston, New Orleans, Baltimore, Memphis, Washington D.C. A series of recurring epidemics of: Smallpox, Cholera, Typhus, Typhoid, Scarlet Fever, Yellow Fever, and Influenza. 1873-1875 North America & Europe Influenza 1878 New Orleans (last great epidemic) Yellow Fever 1885 Plymouth, Pennsylvania Typhoid 1886 Jacksonville, Florida Yellow Fever 1918 Worldwide (high point year) more people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps. Influenza or Spanish Flu.