I am begining to think that this Isham may be the son of the Isham that was in Botetcourt Co Va... And that Isham SR.. was born abt 1742ish to William Matlock of 1702.. Married Martha abt 1788, ( Could be a second wife.)... and according to Jess Armstrong, these were his Children: Martha, Isham, Charles, George, Polly and Claretta. I find it interesting that the Isham that went from VA to SC to GA to ALA names a son Moore.. and that the Isham in Botetourt there was a Moore that at the same time.. I think that Moore and Isham maybe brothers????? ISHAM MEDLOCK, born 1777 in Virginia. Married 1799 to Susannah Williams. They lived in the Greenville Dist. of S. C. and later to Gwinett Co. , Ga. Some children according to descendant were: John Williams, James Isham Henry, Moore, Nathaniel, Lewis Henry and Mastin DeLoney. After the death of Susannah, Isham remarried and went to Cherokee Co., Ala. He died here in 1852 and he and his son, Mastin DeLoney are buried in the Salem Cemetery at Cedar Bluffs, Ala. Isham does not show in Cherokee Co., Ala. in 1840. John R. (who is in Gwinnett Co., Ga. with Isham) does. John R. is in Arkansas in 1850. Isham shows in Cherokee Co., Ala. in 1850 as follows: Iceharn Medlock 73 born Va. Mary 52, born Ga. Didama 23, born Ga. Thomas 15, and Green T. 13 born Ga.