In a message dated 6/21/2006 7:13:03 P.M. Eastern Standard Time, [email protected] writes: --This is ESSENTIAL! I have lost 2 daughters to a VERY rare disease, which is genetic, and recessive. This means that it can jump as many as 20 generations. For this disease to be passed on, BOTH parents must have the same mutation on the same gene and chromosom. There are only 350 people in the world who have this disorder. It's a horrible disease, with much suffering, for the patient, and the family! We ALL need help with this kind of thing! I didn't marry a cousin, we were not even born in the same state, and I am of Polish descent, he is mostly Danish, with ONE German great grand parent! But his ONE German and my Poles might, somewhere way back have been connected in some way! We NEED to know this stuff! If we had known it we might not have had to go through the terrible loss of our two youngest children! And we wouldn't be worrying now about our grandchildren! Jan Birkner LIVE, FREE genealogy help at www.genealogyforum.org my wife has alzhimers which is caused by apoe gene dispite what you have been told the real history of alz in your family is do you have arteial sclorosis aka hardining of the arteries . the secondary funtion of the gene is to create amyloid protien which causes alz. so do you take lipitor and live for dementia or say so what and get heart attack at 56 Jim Denning -Ygenealogist-MTgenealogist using Genetics to connect Chelsea,Ma.-Woburn,Ma.-denning-dennen-danin-dinan-dinihey-denningston-dinning- carlon-carroll-dever-cogan-malone-heslin-piscopo-mazzola-martini-farrell-mchug h-farley-grimes-lynch-doherty-SanDanto,Ita-Adargh,longford-Revere,Ma-Wintrop,M a.- and ever an growing list List owner of Irish-dna,Piscopo-l-Heslin-l,McHugh-l,Cogan-l-Machelsea-l,Ita-Frosinone-l,Mazzola-l-Duggan-l Project Manager of Chelsea Ma. Genetics Project,Denning&Variants Project-Farrell Genetics Project-The Cogan Project- the Duggan Project- County Longford Project-Frosinone Italy Project-Parramatta-Sydney Project- Hannibal MO-QuincyIL Project-Brighton-NewtonMA Project