I posted what I have so far traced of my mitochondrial lineage, with my haplogroup and mutations from my complete mitochondrial sequence, at http://wc.rootsweb.ancestry.com/cgi-bin/igm.cgi?op=GET&db=doramitochondria&id=I511 My emigrant maternal line ancestor was Anne, the wife of Thomas King of Sudbury. She died there in 1642 after giving birth to her last child. Four of her daughters married and left descendants. Three of them married sons of Edmund Rice, one of the better known and more prolific founding fathers of New England. He was one of the proprietors and early leaders of the town of Sudbury. He was bipolar, and a land speculator, which in those days was rather like my bipolar former landlord buying and selling web sites on the internet. Every time his mood cycled down he got very crotchety, didn't get along with anyone, and left to found a new town, taking with him members of his inner circle, some or more likely most of whom also carried bipolar disorder. He and his fellow travelers were leaders, and many of his kin actively founded other towns near Sudbury and Marlborough. This small group of families proceeded to form little subgroups of families that largely married each other for five generations. It is not proven that all of Thomas King's daughters had the same mother. Little is known of Anne, and she may not have been his first wife. She was not Anne Collins, and I find the evidence that she was Anne Tyce of Shaftesbury unconvincing. People have read together two lines of a will that don't grammatically or logically go together, and there are a number of logical inconsistencies. It is proven that Thomas King was from Shaftesbury, but there is only the shakiest of evidence that any of his children were born there. The family was prosperous and widely connected; Thomas's nephew the mayor of Shaftesbury married the daughter of a business contact of his father's 30 miles away, and people in the textile business in Shaftesbury travelled and lived as far afield as India. In Sudbury Thomas was a leading citizen but extremely quiet, and he may have been just about invisible wherever he went. It would be helpful if descendants of other daughters of Thomas - my own well documented line is from Elizabeth - would be tested. There is the complicating factor that the HVR1 and HVR2 mutations, which is what most people get tested, form an extremely common haplogroup H haplotype - 16519C, 263G, 309.1C (plus or minus a C at that location), 315.1C. The number of C's at 309 is very changeable and virtually has no meaning. It takes atleast an H deep clade test to establish the coding region mutation that defines haplogroup H1, which encompasses a third to half of all the people in haplogroup H. A definitive match can only be shown by a complete sequence, which produces two unique coding region mutations. I am interested in any health consequences of these mutations. Both are protein-changing mutations to a working gene; specifically the NADH dehydrogenase subunit 2 gene. Any effects can't be earthshaking as large numbers of members of this lineage have lived into their 80's and 90's, and some family groupings within it acquired reputations for longevity. On the other hand, I suspect that most members of this lineage who live to be old die of often longstanding, slow developing atherosclerosis. Mutations to the NADH dehydrogenase subunit 2 gene could easily have both effects. The timing of this seems to vary as greatly as that due to any gene; from one's 60's to over age 100. The guy who lived to be over 100 was still walking a mile every day to visit people, and it's highly doubtful that that's coincidence. Exercise multiplies mitochondria, lowers blood lipids, and combats atherosclerosis. Yours, Dora Smith Austin, TX tiggernut24@yahoo.com