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    1. [DNA] Very large set of mtDNA sequences on the GenBank database from Madagascar (08-AUG-2017)
    2. Ian Logan
    3. List A very large set of 2,790 complete mtDNA sequences from Madagascar has appeared on the GenBank database. The sequences come from a variety of Haplogroups; and in the first 200 sequences there are examples from: The African Haplogroups: L0a1b1a1, L0a2, L0a2a1b, L0a2a2a, L0d1c, L0f L1b2, L1c1d, L1c2a2, L1c3a, L1c3c, L2a1a2, L2a1b1a, L2b1a3 L3a-G709A, L3b1a, L3b1a1a, L3d1a1a, L3d1a1a1 L3e1a3a, L3e1d1, L3e3a, L3e3b1, L3f1b4a1 And the Asian Haplogroups: B4a1a1b, E1a1a1, F3b1b, F4b1, M7c1c3, M23, M32c The sequences accompany the paper: Proc Natl Acad Sci U S A. 2017 Aug 8;114(32) 'Genomic landscape of human diversity across Madagascar' Pierron D, et al. Abstract given below, It is difficult to present the data from such a large set of sequences; but the details for the first 200 sequences MF055747-MF055946 are given on my website at: http://www.ianlogan.co.uk/lists/pierron-1.htm and my 'Checker' program also gives the mutation lists: http://www.ianlogan.co.uk/checker/checker-pierron.htm More results will appear as I work through the data. Ian www.ianlogan.co.uk ------------------------------- Abstract Although situated ∼400 km from the east coast of Africa, Madagascar exhibits cultural, linguistic, and genetic traits from both Southeast Asia and Eastern Africa. The settlement history remains contentious; we therefore used a grid-based approach to sample at high resolution the genomic diversity (including maternal lineages, paternal lineages, and genome-wide data) across 257 villages and 2,704 Malagasy individuals. We find a common Bantu and Austronesian descent for all Malagasy individuals with a limited paternal contribution from Europe and the Middle East. Admixture and demographic growth happened recently, suggesting a rapid settlement of Madagascar during the last millennium. However, the distribution of African and Asian ancestry across the island reveals that the admixture was sex biased and happened heterogeneously across Madagascar, suggesting independent colonization of Madagascar from Africa and Asia rather than settlement by an already admixed population. In addition, there are geographic influences on the present genomic diversity, independent of the admixture, showing that a few centuries is sufficient to produce detectable genetic structure in human populations.

    08/17/2017 02:26:00