What difference, if any, will FTDNA's shift to Hg38, make for those who send data to YFull? If three men were positive for A8214 under the old format, why are only two listed as positive under Hg38? A8214 is in a questionable region, but with two or three positive tests is probably valid, but it isn't recognized by HG38. I can't see how the new format helps me--am I alone? Lindsey

Lindsay The matching criterion has been changed. See https://www.familytreedna.com/learn/y-dna-testing/big-y/big-y/ ** A person is considered a match if they have 40 or fewer differences in SNPs with you, and their haplogroup is downstream from your haplogroup or downstream from your four closest parent haplogroups.** Salutations, Jacques Beaugrand -----Original Message----- From: GENEALOGY-DNA [mailto:[email protected]] On Behalf Of Lindsey Britton Sent: 4 décembre 2017 15:06 To: [email protected] Subject: [DNA] Big- Y and Hg 38 What difference, if any, will FTDNA's shift to Hg38, make for those who send data to YFull? If three men were positive for A8214 under the old format, why are only two listed as positive under Hg38? A8214 is in a questionable region, but with two or three positive tests is probably valid, but it isn't recognized by HG38. I can't see how the new format helps me--am I alone? Lindsey ------------------------------- To unsubscribe from the list, please send an email to [email protected] with the word 'unsubscribe' without the quotes in the subject and the body of the message

In that regions, there ARE reliable SNPs. But to tell requires lots of investigation using IGV as well as BLAST/BLAT. That SNP is in a particular spot that, using the only build 38 BAM file I have (my own) shows all reads as map quality zero. In build 37 it shows map quality variable 0 to 3, with lots more reads showing. These are all bad signs. It also depends on read lengths. Some BigYs were done at 101 length, some 160 and a few even more. There is a very very big difference in map quality in that area, whih reads 160 long being more reliable than 101 and 250 much much more reliable. Those files might have different normal read lengths. Build 38 will not in general provide any benefit for almost all SNPs. Of the 38 build 38 (yes, the same number) BED/VCFs I've received only a very few have made "naive statemets" that I should add a SNP to or remove one from my tree. And all of these are clearly borderline cases. Most have been cases where the number of "reads" has crosses the "low read number" theshold". You should at least examine the VCF files of those three people for such things as read numbers and map quality. Doug McDonald -----Original Message----- On Behalf Of Lindsey Britton What difference, if any, will FTDNA's shift to Hg38, make for those who send data to YFull? If three men were positive for A8214 under the old format, why are only two listed as positive under Hg38? A8214 is in a questionable region, but with two or three positive tests is probably valid, but it isn't recognized by HG38. Lindsey