I had to laugh when I reached the passage in the article explaining the "central dogma" of mitochondrial DNA transmission.  "Central dogmas" usually turn out to have exceptions, and are eventually superseded by more nuanced paradigms.  We should have learned that from previous "central dogmas". From the observation that a particular case of mitochondrial heteroplasmy is a 60%/40% mixture of maternal and paternal DNA, it would be wrong to suppose (without evidence) that that ratio was actually the ratio of mitochondrial contributions from both parents in the original zygote.  To make that conclusion, we would have to assume that both maternal and paternal mitochondria have survived and multiplied at exactly the same rate through the course of development and successive generations.  That's not the sort of assumption that should be made lightly, at least not without being discussed explicitly. Question for the group, is mitochondrial heteroplasmy, when present, accurately detected and reported by our favorite vendors? John McCoy(RealMac@aol.com) In a message dated 11/27/2018 8:55:22 AM Pacific Standard Time, msvnhrn@jps.net writes: Here is the article: https://www.sciencealert.com/radical-findings-shows-mitochondrial-dna-can-be-inherited-from-dads-after-all Marleen Van Horne _______________________________________________Email preferences: http://bit.ly/rootswebprefUnsubscribe https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.comPrivacy Statement: https://ancstry.me/2JWBOdY Terms and Conditions: https://ancstry.me/2HDBym9Rootsweb Blog: http://rootsweb.blogRootsWeb is funded and supported by Ancestry.com and our loyal RootsWeb community

FTDNA reports heteroplasmy if it reaches a level of 20%. Ann Turner On Tue, Nov 27, 2018 at 9:06 AM realmac--- via GENEALOGY-DNA < genealogy-dna@rootsweb.com> wrote: > I had to laugh when I reached the passage in the article explaining the > "central dogma" of mitochondrial DNA transmission. "Central dogmas" > usually turn out to have exceptions, and are eventually superseded by more > nuanced paradigms. We should have learned that from previous "central > dogmas". > From the observation that a particular case of mitochondrial heteroplasmy > is a 60%/40% mixture of maternal and paternal DNA, it would be wrong to > suppose (without evidence) that that ratio was actually the ratio of > mitochondrial contributions from both parents in the original zygote. To > make that conclusion, we would have to assume that both maternal and > paternal mitochondria have survived and multiplied at exactly the same rate > through the course of development and successive generations. That's not > the sort of assumption that should be made lightly, at least not without > being discussed explicitly. > Question for the group, is mitochondrial heteroplasmy, when present, > accurately detected and reported by our favorite vendors? > John McCoy(RealMac@aol.com) > In a message dated 11/27/2018 8:55:22 AM Pacific Standard Time, > msvnhrn@jps.net writes: > > Here is the article: > > https://www.sciencealert.com/radical-findings-shows-mitochondrial-dna-can-be-inherited-from-dads-after-all > Marleen Van Horne > _______________________________________________Email preferences: > http://bit.ly/rootswebprefUnsubscribe > https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.comPrivacy > Statement: https://ancstry.me/2JWBOdY Terms and Conditions: > https://ancstry.me/2HDBym9Rootsweb Blog: http://rootsweb.blogRootsWeb is > funded and supported by Ancestry.com and our loyal RootsWeb community > > _______________________________________________ > Email preferences: http://bit.ly/rootswebpref > Unsubscribe > https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.com > Privacy Statement: https://ancstry.me/2JWBOdY Terms and Conditions: > https://ancstry.me/2HDBym9 > Rootsweb Blog: http://rootsweb.blog > RootsWeb is funded and supported by Ancestry.com and our loyal RootsWeb > community >

Hi, FTDNA reports heteroplasmy when it reaches a level of 20% since they changed to NGS sequencing for mtDNA It was closer to 1/3 for most of the time they Sanger sequenced mtDNA. On Tue, Nov 27, 2018 at 11:23 AM Ann Turner <dnacousins@gmail.com> wrote: > FTDNA reports heteroplasmy if it reaches a level of 20%. > > Ann Turner --- Regards, Rebekah A. Canada Volunteer Administrator, Family Tree DNA <https://affiliate.familytreedna.com/idevaffiliate.php?id=598> Author, Haplogroup <https://haplogroup.org> -- PRIVILEGED & CONFIDENTIAL COMMUNICATION -- This communication is privileged and contains confidential information. If it has been sent to you in error, please disregard, reply to the sender that you received it in error, and delete it. Any distribution or other reproduction is strictly prohibited.

One of the references on the ISOGG Facebook page was to a Science article from 2016 - Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization [Science, Vol. 353, p. 394, 22 July 2016]. I think this was studied in C. Elegans spermatozoa - not necessary the best model to humans! However, as almost any protein can have genetic mutations in it at some stage - could deficiencies in the structure of the endonuclease G equivalent in the human situation result in less than optimal destruction of those male mitochondria? Brian -----Original Message----- From: realmac--- via GENEALOGY-DNA <genealogy-dna@rootsweb.com> Sent: 27 November 2018 17:06 To: genealogy-dna@rootsweb.com Cc: realmac@aol.com Subject: [DNA] Re: Paternal transmission pf mtDNA to offspring in humans I had to laugh when I reached the passage in the article explaining the "central dogma" of mitochondrial DNA transmission. "Central dogmas" usually turn out to have exceptions, and are eventually superseded by more nuanced paradigms. We should have learned that from previous "central dogmas". From the observation that a particular case of mitochondrial heteroplasmy is a 60%/40% mixture of maternal and paternal DNA, it would be wrong to suppose (without evidence) that that ratio was actually the ratio of mitochondrial contributions from both parents in the original zygote. To make that conclusion, we would have to assume that both maternal and paternal mitochondria have survived and multiplied at exactly the same rate through the course of development and successive generations. That's not the sort of assumption that should be made lightly, at least not without being discussed explicitly. Question for the group, is mitochondrial heteroplasmy, when present, accurately detected and reported by our favorite vendors? John McCoy(RealMac@aol.com) In a message dated 11/27/2018 8:55:22 AM Pacific Standard Time, msvnhrn@jps.net writes: Here is the article: https://www.sciencealert.com/radical-findings-shows-mitochondrial-dna-can-be-inherited-from-dads-after-all Marleen Van Horne _______________________________________________Email preferences: http://bit.ly/rootswebprefUnsubscribe https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.comPrivacy Statement: https://ancstry.me/2JWBOdY Terms and Conditions: https://ancstry.me/2HDBym9Rootsweb Blog: http://rootsweb.blogRootsWeb is funded and supported by Ancestry.com and our loyal RootsWeb community _______________________________________________ Email preferences: http://bit.ly/rootswebpref Unsubscribe https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.com Privacy Statement: https://ancstry.me/2JWBOdY Terms and Conditions: https://ancstry.me/2HDBym9 Rootsweb Blog: http://rootsweb.blog RootsWeb is funded and supported by Ancestry.com and our loyal RootsWeb community

I see the authors also mention endonuclease G in the discussion section. This article is going to spawn a lot of research! Ann Turner On Tue, Nov 27, 2018 at 1:17 PM <bps@norvic8.force9.co.uk> wrote: > One of the references on the ISOGG Facebook page was to a Science article > from 2016 - Mitochondrial endonuclease G mediates breakdown of paternal > mitochondria upon fertilization [Science, Vol. 353, p. 394, 22 July 2016]. > > I think this was studied in C. Elegans spermatozoa - not necessary the > best model to humans! > > However, as almost any protein can have genetic mutations in it at some > stage - could deficiencies in the structure of the endonuclease G > equivalent in the human situation result in less than optimal destruction > of those male mitochondria? > > Brian > > -----Original Message----- > From: realmac--- via GENEALOGY-DNA <genealogy-dna@rootsweb.com> > Sent: 27 November 2018 17:06 > To: genealogy-dna@rootsweb.com > Cc: realmac@aol.com > Subject: [DNA] Re: Paternal transmission pf mtDNA to offspring in humans > > I had to laugh when I reached the passage in the article explaining the > "central dogma" of mitochondrial DNA transmission. "Central dogmas" > usually turn out to have exceptions, and are eventually superseded by more > nuanced paradigms. We should have learned that from previous "central > dogmas". > > From the observation that a particular case of mitochondrial heteroplasmy > is a 60%/40% mixture of maternal and paternal DNA, it would be wrong to > suppose (without evidence) that that ratio was actually the ratio of > mitochondrial contributions from both parents in the original zygote. To > make that conclusion, we would have to assume that both maternal and > paternal mitochondria have survived and multiplied at exactly the same rate > through the course of development and successive generations. That's not > the sort of assumption that should be made lightly, at least not without > being discussed explicitly. > > Question for the group, is mitochondrial heteroplasmy, when present, > accurately detected and reported by our favorite vendors? > > John McCoy(RealMac@aol.com) > In a message dated 11/27/2018 8:55:22 AM Pacific Standard Time, > msvnhrn@jps.net writes: > > Here is the article: > > https://www.sciencealert.com/radical-findings-shows-mitochondrial-dna-can-be-inherited-from-dads-after-all > Marleen Van Horne > _______________________________________________Email preferences: > http://bit.ly/rootswebprefUnsubscribe > https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.comPrivacy > Statement: https://ancstry.me/2JWBOdY Terms and Conditions: > https://ancstry.me/2HDBym9Rootsweb Blog: http://rootsweb.blogRootsWeb is > funded and supported by Ancestry.com and our loyal RootsWeb community > > _______________________________________________ > Email preferences: http://bit.ly/rootswebpref Unsubscribe > https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.com > Privacy Statement: https://ancstry.me/2JWBOdY Terms and Conditions: > https://ancstry.me/2HDBym9 Rootsweb Blog: http://rootsweb.blog RootsWeb > is funded and supported by Ancestry.com and our loyal RootsWeb community > > _______________________________________________ > Email preferences: http://bit.ly/rootswebpref > Unsubscribe > https://lists.rootsweb.com/postorius/lists/genealogy-dna@rootsweb.com > Privacy Statement: https://ancstry.me/2JWBOdY Terms and Conditions: > https://ancstry.me/2HDBym9 > Rootsweb Blog: http://rootsweb.blog > RootsWeb is funded and supported by Ancestry.com and our loyal RootsWeb > community >

Ann/Brian I have now seen the paper about paternal inheritance of mtDNA. The authors make a good case for showing that in 3 pedigrees there are people who have mixed 'heteroplasmic' mitochondrial DNA. They identified persons with mixtures of Haplogroups: R0a1 & H1a1, R0a1 & U5b1d1c, K1b2a & H, K1b2a & T2a1a, K2b1a1a & J2a1a1a2, K2b1a1 & K2a7 It is possible that in the past other people have found similar mixed 'heteroplasmic' results - but they have not been noted as indicating paternal inheritance. However, this is clearly an unusual occurrence. Let us wait and see what other sets of results appear ... Ian ---------------------------------------------------------------------- On 28/11/2018 12:55, Ann Turner wrote: > I see the authors also mention endonuclease G in the discussion section. > This article is going to spawn a lot of research! > > Ann Turner > > On Tue, Nov 27, 2018 at 1:17 PM <bps@norvic8.force9.co.uk> wrote: > >> One of the references on the ISOGG Facebook page was to a Science article >> from 2016 - Mitochondrial endonuclease G mediates breakdown of paternal >> mitochondria upon fertilization [Science, Vol. 353, p. 394, 22 July 2016]. >> >> I think this was studied in C. Elegans spermatozoa - not necessary the >> best model to humans! >> >> However, as almost any protein can have genetic mutations in it at some >> stage - could deficiencies in the structure of the endonuclease G >> equivalent in the human situation result in less than optimal destruction >> of those male mitochondria? >> >> Brian