Hi Roberta, Well, I happen to be aware of a Palatine line with my surname who arrived at about that time. However, I am not aware of any medical studies regarding my surname. Says because 4 individuals appeared to have common descent, that may be an indication that an autoimmune weakness may be present(?), and therefore the study. It was stated that 4 individuals was more than the expected probabilities. I guess the argument there could be 'did more than 4 work in the same industry?' (In order to compare to environmental factors, for example.) Let me see, the thought is that the cancers are associated with atDNA regions by descent. In answer to your question, the SNP and Mbp start locations on chromosome 3 are listed. For me, I have small segment matches to some of my estimated 4th to 9th cousins interspersed between some of those locations. None from Germany that I know of, and none with an exact match to the locations listed. However, I did notice that using my cousin calculator, some of my own tiny segment matches on chr 3 between 48 and 53 Mbp have a predicted cousin level in the range of 20th to 32nd cousin. (Roughly dating back 1,000 to 1,600 years). The authors suggest early screening for a better chance of recovery. The conflicts of interest are listed on the web page. Now, I suppose the question is whether or not vendors will consider this to be medically related, and remove the segments from the results. Which would lower the chance of finding these cousins for genealogical purposes, but keep them available for medical purposes. - Dave Hamm RE: On 12/22/2015 8:33 PM, genealogy-dna-request@rootsweb.com wrote: > Date: Tue, 22 Dec 2015 20:33:57 -0500 > From: "Roberta Estes"<robertajestes@att.net> > Subject: Re: [DNA] Combined Genetic and Genealogic Studies Uncover a > Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a > Common Ancestor from the 1700s > To: "'steven perkins'"<scperkins@gmail.com>, > <genealogy-dna@rootsweb.com> > Message-ID:<00c701d13d21$ff0b70d0$fd225270$@att.net> > Content-Type: text/plain; charset="UTF-8" > > The irritating part is that the immigrant couple is not identified. What possible good could this be to anyone without that information? > > Roberta Estes > > -----Original Message----- > From:genealogy-dna-bounces@rootsweb.com [mailto:genealogy-dna-bounces@rootsweb.com] On Behalf Of steven perkins via > Sent: Tuesday, December 22, 2015 7:41 PM > To: genealogy-dna > Subject: [DNA] Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s > > http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005633 > > Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s