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    1. Re: [DNA] Denisovan8 mtDNA sequence now on GenBank (21-NOV-2015)
    2. Thomas Krahn via
    3. Dear Ian, Thanks very much for your updates and analysis. I have made something similar with the Y chromosome side for Denisova8. This is of course way more speculative since the few reads most of the time only have a 1x coverage and the most part consists of huge gaps. Anyways, since there are no Neanderthal Y sequences, we're grasping for straws. Finally some really ancient Y-DNA. https://drive.google.com/file/d/0B2lGDNiBM85QUllVS1g3eFVSdHc/view I was actually surprised that in context with gorilla, chimp and A00 sequences, some of the base changes made sense. We can see multiple A0-T markers that we previously discovered from A00 samples confirmed. At least 20 mutations match up with chimp and gorilla and can therefore be attributed to the novel branch A00-T with significant confidence. Note that this number of 20 ancestral Denisova8 alleles is significantly higher than the 8 phylogenetic inconsistent mutations that I've found. I have also registered 130 mutations that could potentially be derived in Denisova, however they are purely speculative. I have not filtered them for quality or for stable regions. Only consider them with a grain of salt. They are not worth a publication, but when more ancient Y-DNA sequences become available they may be used for comparison. Thomas On 11/24/2015 11:39 AM, Ian Logan via wrote: > List > > Readers might be interested to see the mitochondrial details > and abstract that accompany this paper: > > "Nuclear and mitochondrial DNA sequences from two Denisovan individuals" > Sawyer,S., Renaud,G., Viola,B., Prufer,K., Kelso,J. and Paabo,S. > > A free download on: > http://www.pnas.org/content/early/2015/11/11/1519905112.full.pdf > > The date of divergence of the Denisovan line from the modern human line > would appear to be around 900-1,000 kya. > >

    11/25/2015 01:53:03