http://www.genengnews.com/gen-news-highlights/1000-genomes-project-wraps-up-at-2-504/81251813/ "Offering a glimpse of the bright gleam of victory, the 1000 Genomes Project Consortium has announced that it has accomplished its goal, the creation of a comprehensive catalog of human genomic variation. When it first mustered an international team of scientists back in 2008, the project planned to build a reference dataset that would show how rare genomic variants were distributed among populations around the world—or at least within a microcosm of 1000 individuals. Now, seven years later, the project has reconstructed the genomes of 2,504 individuals from 26 populations across Africa, East and South Asia, Europe, and the Americas. The culmination of the project was described in a pair of papers that appeared September 30 in Nature, along with an editorial that carried a Churchillian title, “Human genomics: The end of the start for population sequencing.” Presumably, the beginning of the end of population sequencing would see researchers and clinicians leveraging genomic variant information to develop improved diagnostics and treatments, in addition to new methods of prevention." Continued at link above. -- Steven C. Perkins SCPerkins@gmail.com http://stevencperkins.com/ Indigenous Peoples' Rights http://intelligent-internet.info/law/ipr2.html Indigenous & Ethnic Minority Legal News http://iemlnews.blogspot.com/ Online Journal of Genetics and Genealogy http://jgg-online.blogspot.com/ S.C. Perkins' Genealogy Page http://stevencperkins.com/genealogy.html S.C. Perkins' Genealogy Blog http://scpgen.blogspot.com/

The original papers show two big bold things about this project: 1) very poor "coverage" at 7.4% (i.e. average number of sequencing reads at each site) 2) a measured 5% error rate for SNP discovery. It seems that this thing was medically directed, and thus that medical researchers accept bad data. Of course, they can tolerate that and even love it, because each variant, real or not, could theoretically support a whole grant to verify it. Doug McDonald -----Original Message----- http://www.genengnews.com/gen-news-highlights/1000-genomes-project-wraps-up-at-2-504/81251813/ "Offering a glimpse of the bright gleam of victory, the 1000 Genomes Project Consortium has announced that it has accomplished its goal, the creation of a comprehensive catalog of human genomic variation. When it first mustered an international team of scientists back in 2008, the project planned to build a reference dataset that would show how rare genomic variants were distributed among populations around the world—or at least within a microcosm of 1000 individuals. Now, seven years later, the project has reconstructed the genomes of 2,504 individuals from 26 populations across Africa, East and South Asia, Europe, and the Americas.