Doug, I think when the 1000 genome project was set up, the testing technology was still evolving, and for its time it was as good as could be had. Even with error rates, it set up an important base line resource to build from, where none existed. I think it has been an amazingly good project and there has been many good consequences for genetic genealogist, including much Y SNP discovery. Even if there were 5% error rates, by mass testing, useful reliable data is gradually revealed. For example Y SNPs occurred over time in a sequential order, and we as genetic genealogists can relatively easily spot the testing errors. I believe Full Genomes Corp analysed some of the raw data, and have it available to compare with customer results, at least for Y. They have one L617 result amongst this, which is of personal interest to me. Using this result for comparison has been hugely beneficial to me, and if 1 in 20 Y SNPs were in error, it from my perspective has negligible ill effects for what I am doing. The 1000 genomes project has to be judged by its place in an evolving world. It was the sharp end of research for its time. John. Sent from my iPad > On 7/10/2015, at 8:00 am, McDonald@lists3.rootsweb.com wrote: > > The original papers show two big bold things about this project: > > 1) very poor "coverage" at 7.4% (i.e. average number of sequencing reads at each site) > > 2) a measured 5% error rate for SNP discovery. > > It seems that this thing was medically directed, and thus that medical researchers > accept bad data. Of course, they can tolerate that and even love it, because > each variant, real or not, could theoretically support a whole grant to verify it. > > Doug McDonald > > -----Original Message----- > > http://www.genengnews.com/gen-news-highlights/1000-genomes-project-wraps-up-at-2-504/81251813/ > > "Offering a glimpse of the bright gleam of victory, the 1000 Genomes > Project Consortium has announced that it has accomplished its goal, the > creation of a comprehensive catalog of human genomic variation. When it > first mustered an international team of scientists back in 2008, the > project planned to build a reference dataset that would show how rare > genomic variants were distributed among populations around the world—or at > least within a microcosm of 1000 individuals. Now, seven years later, the > project has reconstructed the genomes of 2,504 individuals from 26 > populations across Africa, East and South Asia, Europe, and the Americas. > > > > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message