Thanks Andrea, at least I know it's not just ME! LOL Wonder if that means we are getting the upgraded site already? They should have a site notice letting us know something is going on, but that part looks just peachy when I go there. On Thu, Nov 12, 2015 at 12:38 PM, Andrea Badger <andreabadger718@gmail.com> wrote: > Yes, it is down for me. I think they are doing site updates. > -Andrea Badger > > On Thu, Nov 12, 2015 at 10:26 AM, Franklin Genetics via < > genealogy-dna@rootsweb.com> wrote: > >> Is anyone else having trouble logging into their 23andME today? Was >> working fine early this morning. Am wondering if updates are going on now >> as it just sits and spins and does nada toward actually logging in once >> the >> signin info is entered. >> >> sigh.. >> thx >> >> ------------------------------- >> To unsubscribe from the list, please send an email to >> GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without >> the quotes in the subject and the body of the message > > > -- Lisa R Franklin RN,BSN Admin, Franklin Y DNA Project http://trackingyourroots.com/FranklinGenetics/ FranklinGenetics@gmail.com http://trackingyourroots.com/DNA (How To presentation (23andme), tips, & helps. *2**3**&**m**e**: **The World's Largest database & coincidentally the ONLY one with all the tools you need for genealogy and DNA!--* http://refer.23andme.com/v2/share/6158544791499756901/4672616e6b6c696e47656e657469637340676d61696c2e636f6d BEST GENETIC GENEALOGY BOOK! http://www.amazon.com/Genetic-Genealogy-Emily-D-Aulicino-ebook/dp/B00HJJWBU2/ref=sr_1_1?ie=UTF8&qid=1391174801&sr=8-1&keywords=Genetic+Genealogy
Is anyone else having trouble logging into their 23andME today? Was working fine early this morning. Am wondering if updates are going on now as it just sits and spins and does nada toward actually logging in once the signin info is entered. sigh.. thx
I figured out how to figure out how many Matches with whom I have Sharing that I expect to lose. If you sort your matches by: Click on Contact Status, the first category to display is Sharing Genomes Introduction Accepted View Conversation. IOW none of this first set of people have made themselves Sharing Genomes Public Matches View Conversation (approximately the next category). And despite Jim B's sanguine belief that 23 thinks these people are all NOT ANONYMOUS to me at least, I have seen no indication anywhere that that is the case. (It's my fault that I didn't ask that Jim B show me where he got the notion that these people are no longer Anonymous by 23's new definition.) IOW if I'm correct and all these people out of my ~1000 matches, are deleted, I'll lose 30% of my matches including my top match besides my sis. And she'll lose ~18% (and that same top match). And also I haven't seen their new email system, but all these nicely filed emails would be lost (the only part of their email system that used to be decent). It occurs to me that it's far worse than 30% if you count only % of 3rd or 4th projected cousins. Hmm, it's ~60/150 = 40%. BTW in the column on 23 that discusses the change, the last entry by STAFF as of ~1/2 hr ago was Due to Technical Issues, the (whatever) has been delayed until 11/12. IMO I expect that the Technical Issue is: Whatever test run they ran determined that LOTS of Matches that SHOULDN'T be deleted WOULD be deleted by the program that the (probably) contract personnel had concocted to do the deleting.
Steven, I hear that the Denisovan sequences can be seen at the UCSC Browser, but I haven;t tried this. I also cannot seem to find any Neanderthal sequences at NCBI, so as of now the Neanderthal Browser that I mentioned earlier is the only way I see to access the Neanderthal sequence. I have now been able to use this, however, to confirm that several of my SNPs in the PRDM2 segment match the Neanderthal sequence, so it seems clear that this is a remnant of a distant Neanderthal ancestor's DNA. Obed On Wed, Nov 11, 2015 at 4:54 PM, steven perkins via < genealogy-dna@rootsweb.com> wrote: > Obed: > > Is there a comparable Denisovan Genome Browser? > > Geno 2 gave me 2.6% Neanderthal and 3.3% Denisovan ancestry. I understand > that the Neanderthal is the only one they report with the new Geno 2 Next > Generation test and the results are usually around half the size as before. > > Thanks, > > Steven > > > -----Original Message----- > > From: Obed W Odom via <genealogy-dna@rootsweb.com> > > To: DNA Genealogy Mailing List <genealogy-dna@rootsweb.com> > > Sent: Wed, Nov 11, 2015 10:56 am > > Subject: Re: [DNA] What gives with this 128,777-bp segment on chromosome > 1? > > > > > > I have confirmed at the Neandertal Browser > > < > > > > > http://neandertal.ensemblgenomes.org/Homo_sapiens/Location/View?r=1:13942870-13942900 > > > > > , > > which uses Build hg18, that my G to A SNP (rs114034230) at GRCh37 > > (hg19) > > location 14070302 does indeed agree with the change from G to A in > > going > > from the human to the Neanderthal sequence at the corresponding > > hg18 > > location (13942889). This SNP is one of the 366 mismatches between > > the > > GRCh37 (hg19) and the Chr1 "alternate" sequence in the region I > > gave > > earlier. I will compare some of my other "mismatch" SNPs to the > > Neanderthal > > sequence, but I now believe that I do indeed have a Neanderthal > > sequence on > > 1 copy of chr1 from GRCh37 location 14000722 thru location > > 14129498! This > > Neanderthal segment has probably been published somewhere, but > > it is news > > to me. > > > > Obed > > > > > > -- > Steven C. Perkins SCPerkins@gmail.com http://stevencperkins.com/ > Indigenous Peoples' Rights http://intelligent-internet.info/law/ipr2.html > Indigenous & Ethnic Minority Legal News http://iemlnews.blogspot.com/ > Online Journal of Genetics and Genealogy http://jgg-online.blogspot.com/ > S.C. Perkins' Genealogy Page http://stevencperkins.com/genealogy.html > S.C. Perkins' Genealogy Blog http://scpgen.blogspot.com/ > > ------------------------------- > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without > the quotes in the subject and the body of the message >
I got this message, does it mean I have to do something, I have first initial, last name, am I to change it to show my first name as well? "The Countries of Ancestry Lab is no longer available. Parts of this >> feature will be available to you once you transition into the new >> experience." > >
slow but I am in On Thu, Nov 12, 2015 at 10:57 AM, Roberta Estes via < genealogy-dna@rootsweb.com> wrote: > With the luck you're having today with vendor sites, maybe you should go > for a walk:) > > Roberta > > -----Original Message----- > From: genealogy-dna-bounces@rootsweb.com [mailto: > genealogy-dna-bounces@rootsweb.com] On Behalf Of Franklin Genetics via > Sent: Thursday, November 12, 2015 1:26 PM > To: ISOGG@yahoogroups.com; genealogy-dna@rootsweb.com; > autosomal-dna-l@rootsweb.com > Subject: [DNA] 23andme down? > > Is anyone else having trouble logging into their 23andME today? Was > working fine early this morning. Am wondering if updates are going on now > as it just sits and spins and does nada toward actually logging in once the > signin info is entered. > > sigh.. > thx > > ------------------------------- > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without > the quotes in the subject and the body of the message > > > > ------------------------------- > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without > the quotes in the subject and the body of the message >
They tried to start the update yesterday but some glitch caused them to postpone until today. We may have a few days of assorted hiccups. RPaine -----Original Message----- From: Franklin Genetics via Sent: Thursday, November 12, 2015 10:42 AM To: Andrea Badger Cc: genealogy-dna@rootsweb.com Subject: Re: [DNA] 23andme down? Thanks Andrea, at least I know it's not just ME! LOL Wonder if that means we are getting the upgraded site already? They should have a site notice letting us know something is going on, but that part looks just peachy when I go there. On Thu, Nov 12, 2015 at 12:38 PM, Andrea Badger <andreabadger718@gmail.com> wrote: > Yes, it is down for me. I think they are doing site updates. > -Andrea Badger > > On Thu, Nov 12, 2015 at 10:26 AM, Franklin Genetics via < > genealogy-dna@rootsweb.com> wrote: > >> Is anyone else having trouble logging into their 23andME today? Was >> working fine early this morning. Am wondering if updates are going on >> now >> as it just sits and spins and does nada toward actually logging in once >> the >> signin info is entered. >> >> sigh.. >> thx>> >> ------------------------------- >> To unsubscribe from the list, please send an email to >> GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without >> the quotes in the subject and the body of the message > > > -- Lisa R Franklin RN,BSN Admin, Franklin Y DNA Project http://trackingyourroots.com/FranklinGenetics/ FranklinGenetics@gmail.com http://trackingyourroots.com/DNA (How To presentation (23andme), tips, & helps. *2**3**&**m**e**: **The World's Largest database & coincidentally the ONLY one with all the tools you need for genealogy and DNA!--* http://refer.23andme.com/v2/share/6158544791499756901/4672616e6b6c696e47656e657469637340676d61696c2e636f6d BEST GENETIC GENEALOGY BOOK! http://www.amazon.com/Genetic-Genealogy-Emily-D-Aulicino-ebook/dp/B00HJJWBU2/ref=sr_1_1?ie=UTF8&qid=1391174801&sr=8-1&keywords=Genetic+Genealogy ------------------------------- To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message
They have started doing the update, I have gotten a few error messages / time outs and things are moving really slow. Some of the old links are no longer working. RPaine. -----Original Message----- From: Franklin Genetics via Sent: Thursday, November 12, 2015 10:26 AM To: ISOGG@yahoogroups.com ; genealogy-dna@rootsweb.com ; autosomal-dna-l@rootsweb.com Subject: [DNA] 23andme down? Is anyone else having trouble logging into their 23andME today? Was working fine early this morning. Am wondering if updates are going on now as it just sits and spins and does nada toward actually logging in once the signin info is entered. sigh.. thx------------------------------- To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message
Yes, it is down for me. I think they are doing site updates. -Andrea Badger On Thu, Nov 12, 2015 at 10:26 AM, Franklin Genetics via < genealogy-dna@rootsweb.com> wrote: > Is anyone else having trouble logging into their 23andME today? Was > working fine early this morning. Am wondering if updates are going on now > as it just sits and spins and does nada toward actually logging in once the > signin info is entered. > > sigh.. > thx > > ------------------------------- > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without > the quotes in the subject and the body of the message
http://www.fiercemedicaldevices.com/story/fda-cracks-down-genetic-test-makers-direct-consumer-marketing/2015-11-09 -- Steven C. Perkins SCPerkins@gmail.com http://stevencperkins.com/ Indigenous Peoples' Rights http://intelligent-internet.info/law/ipr2.html Indigenous & Ethnic Minority Legal News http://iemlnews.blogspot.com/ Online Journal of Genetics and Genealogy http://jgg-online.blogspot.com/ S.C. Perkins' Genealogy Page http://stevencperkins.com/genealogy.html S.C. Perkins' Genealogy Blog http://scpgen.blogspot.com/
An interesting example of long-read sequencing. Waiting for this to be regularly applied in human genome se q uenc ing . ====================================== Single-molecule sequencing of the desiccation-tolerant grass Oropetium thomaeum. Open Source: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature15714.html Robert VanBuren, Doug Bryant, Patrick P. Edger, Haibao Tang, Diane Burgess, Dinakar Challabathula, Kristi Spittle, Richard Hall, Jenny Gu, Eric Lyons, Michael Freeling, Dorothea Bartels, Boudewijn Ten Hallers, Alex Hastie, Todd P. Michael & Todd C. Mockler Nature (2015) doi:10.1038/nature15714 Received 28 April 2015 Accepted 10 September 2015 Published online 11 November 2015 Plant genomes, and eukaryotic genomes in general, are typically repetitive, polyploid and heterozygous, which complicates genome assembly1. The short read lengths of early Sanger and current next-generation sequencing platforms hinder assembly through complex repeat regions, and many draft and reference genomes are fragmented, lacking skewed GC and repetitive intergenic sequences, which are gaining importance due to projects like the Encyclopedia of DNA Elements (ENCODE)2. Here we report the whole-genome sequencing and assembly of the desiccation-tolerant grass Oropetium thomaeum. *Using only single-molecule real-time sequencing, which generates long (>16 kilobases) reads with random errors, we assembled 99% (244 megabases) of theOropetium genome into 625 contigs with an N50 length of 2.4 megabases*. Oropetium is an example of a ‘near-complete’ draft genome which includes gapless coverage over gene space as well as intergenic sequences such as centromeres, telomeres, transposable elements and rRNA clusters that are typically unassembled in draft genomes. Oropetium has 28,466 protein-coding genes and 43% repeat sequences, yet with 30% more compact euchromatic regions it is the smallest known grass genome. The Oropetium genome demonstrates the utility of single-molecule real-time sequencing for assembling high-quality plant and other eukaryotic genomes, and serves as a valuable resource for the plant comparative genomics community. [Line breaks and bolding added by SCP] -- Steven C. Perkins SCPerkins@gmail.com http://stevencperkins.com/ Indigenous Peoples' Rights http://intelligent-internet.info/law/ipr2.html Indigenous & Ethnic Minority Legal News http://iemlnews.blogspot.com/ Online Journal of Genetics and Genealogy http://jgg-online.blogspot.com/ S.C. Perkins' Genealogy Page http://stevencperkins.com/genealogy.html S.C. Perkins' Genealogy Blog http://scpgen.blogspot.com/
Obed: Is there a comparable Denisovan Genome Browser? Geno 2 gave me 2.6% Neanderthal and 3.3% Denisovan ancestry. I understand that the Neanderthal is the only one they report with the new Geno 2 Next Generation test and the results are usually around half the size as before. Thanks, Steven -----Original Message----- > From: Obed W Odom via <genealogy-dna@rootsweb.com> > To: DNA Genealogy Mailing List <genealogy-dna@rootsweb.com> > Sent: Wed, Nov 11, 2015 10:56 am > Subject: Re: [DNA] What gives with this 128,777-bp segment on chromosome 1? > > > I have confirmed at the Neandertal Browser > < > > http://neandertal.ensemblgenomes.org/Homo_sapiens/Location/View?r=1:13942870-13942900 > > > , > which uses Build hg18, that my G to A SNP (rs114034230) at GRCh37 > (hg19) > location 14070302 does indeed agree with the change from G to A in > going > from the human to the Neanderthal sequence at the corresponding > hg18 > location (13942889). This SNP is one of the 366 mismatches between > the > GRCh37 (hg19) and the Chr1 "alternate" sequence in the region I > gave > earlier. I will compare some of my other "mismatch" SNPs to the > Neanderthal > sequence, but I now believe that I do indeed have a Neanderthal > sequence on > 1 copy of chr1 from GRCh37 location 14000722 thru location > 14129498! This > Neanderthal segment has probably been published somewhere, but > it is news > to me. > > Obed > > -- Steven C. Perkins SCPerkins@gmail.com http://stevencperkins.com/ Indigenous Peoples' Rights http://intelligent-internet.info/law/ipr2.html Indigenous & Ethnic Minority Legal News http://iemlnews.blogspot.com/ Online Journal of Genetics and Genealogy http://jgg-online.blogspot.com/ S.C. Perkins' Genealogy Page http://stevencperkins.com/genealogy.html S.C. Perkins' Genealogy Blog http://scpgen.blogspot.com/
Just wait until you tell your relatives that they are Neanderthals -----Original Message----- From: Obed W Odom via <genealogy-dna@rootsweb.com> To: DNA Genealogy Mailing List <genealogy-dna@rootsweb.com> Sent: Wed, Nov 11, 2015 10:56 am Subject: Re: [DNA] What gives with this 128,777-bp segment on chromosome 1? I have confirmed at the Neandertal Browser < http://neandertal.ensemblgenomes.org/Homo_sapiens/Location/View?r=1:13942870-13942900> , which uses Build hg18, that my G to A SNP (rs114034230) at GRCh37 (hg19) location 14070302 does indeed agree with the change from G to A in going from the human to the Neanderthal sequence at the corresponding hg18 location (13942889). This SNP is one of the 366 mismatches between the GRCh37 (hg19) and the Chr1 "alternate" sequence in the region I gave earlier. I will compare some of my other "mismatch" SNPs to the Neanderthal sequence, but I now believe that I do indeed have a Neanderthal sequence on 1 copy of chr1 from GRCh37 location 14000722 thru location 14129498! This Neanderthal segment has probably been published somewhere, but it is news to me. Obed On Wed, Nov 11, 2015 at 2:07 AM, Obed W Odom <owodom@utexas.edu> wrote: > I mentioned this segment before, but the more I study it the less I > understand it. In looking at my whole-genome sequence in the region of the > PRDM2 gene at locations 14026714 thru 14151574 of chromosome 1, I decided > to BLAST the Build GRCh37 sequence of PRDM2 against the human genome to see > if there were other similar sequences which could have caused mapping to > the wrong sequence. The only similar sequence I found was an "alternate" > sequence covering the same region, but with several mismatches to the > GRCh37 sequence. In looking at these mismatches more closely, I found that > one of my chomosome1 copies matched every one of the mismatches between the > GRCh37 and "alternate" sequences. In addition, the 1000 Genomes database > shows an SNP at each of these mismatch positions. Many of these SNPs, > according to 1000 Genomes, have identical frequencies, indicating that they > are always found together (i.e., on the same chromosome). Most of these > frequencies are in the 0.03 to 0.04 area with a few as low as 0.012. In > other words, they are in the "uncommon" but not "extremely rare" category. > I have since extended the region of comparison and found that it extends > from GRCh37 chr1 location 14000722 to location 14129498, beginning somewhat > upstream of the PRDM2 gene and ending before the last small coding exon of > PRDM2. This span includes 366 mismatches between the GRCh37 (or GRCh38) > reference sequence and the "alternate" chr1 sequence (locations 13799083 to > 13927951 of CHM1_1.1; ID: ref|NC_018912.2 > <https://www.ncbi.nlm.nih.gov/nucleotide/528476670?report=genbank&log$=nuclalign&blast_rank=1&RID=3ZJ88E01113> > > My question is how did all of these SNPs get together and stay together on > one piece of DNA. Maybe the more important question is how they got > together since the rate of crossover within a 128-kb segment would be only > about 0.13 cM, or 0.0013 per generation. By the way this piece of DNA > seems to be pretty old from 1000 Genome frequency data for various > populations. The highest frequency by far, about 0.14, is in the South > Asian group, with European and East Asian frequencies being about 0.02, and > the African and American Indian about 0.003 and 0-0.0013, respectively. The > low African frequency is reminiscent of the Neanderthal introgression of > about 50,000 years ago, as I recall. Could this be something like that or > indeed one of the pieces of Neanderthal DNA itself? > > Hope to hear from someone more knowledgeable than myself about this ( > Ann, Greg, Thomas, others?) > ------------------------------- To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message
I have confirmed at the Neandertal Browser < http://neandertal.ensemblgenomes.org/Homo_sapiens/Location/View?r=1:13942870-13942900> , which uses Build hg18, that my G to A SNP (rs114034230) at GRCh37 (hg19) location 14070302 does indeed agree with the change from G to A in going from the human to the Neanderthal sequence at the corresponding hg18 location (13942889). This SNP is one of the 366 mismatches between the GRCh37 (hg19) and the Chr1 "alternate" sequence in the region I gave earlier. I will compare some of my other "mismatch" SNPs to the Neanderthal sequence, but I now believe that I do indeed have a Neanderthal sequence on 1 copy of chr1 from GRCh37 location 14000722 thru location 14129498! This Neanderthal segment has probably been published somewhere, but it is news to me. Obed On Wed, Nov 11, 2015 at 2:07 AM, Obed W Odom <owodom@utexas.edu> wrote: > I mentioned this segment before, but the more I study it the less I > understand it. In looking at my whole-genome sequence in the region of the > PRDM2 gene at locations 14026714 thru 14151574 of chromosome 1, I decided > to BLAST the Build GRCh37 sequence of PRDM2 against the human genome to see > if there were other similar sequences which could have caused mapping to > the wrong sequence. The only similar sequence I found was an "alternate" > sequence covering the same region, but with several mismatches to the > GRCh37 sequence. In looking at these mismatches more closely, I found that > one of my chomosome1 copies matched every one of the mismatches between the > GRCh37 and "alternate" sequences. In addition, the 1000 Genomes database > shows an SNP at each of these mismatch positions. Many of these SNPs, > according to 1000 Genomes, have identical frequencies, indicating that they > are always found together (i.e., on the same chromosome). Most of these > frequencies are in the 0.03 to 0.04 area with a few as low as 0.012. In > other words, they are in the "uncommon" but not "extremely rare" category. > I have since extended the region of comparison and found that it extends > from GRCh37 chr1 location 14000722 to location 14129498, beginning somewhat > upstream of the PRDM2 gene and ending before the last small coding exon of > PRDM2. This span includes 366 mismatches between the GRCh37 (or GRCh38) > reference sequence and the "alternate" chr1 sequence (locations 13799083 to > 13927951 of CHM1_1.1; ID: ref|NC_018912.2 > <https://www.ncbi.nlm.nih.gov/nucleotide/528476670?report=genbank&log$=nuclalign&blast_rank=1&RID=3ZJ88E01113> > > My question is how did all of these SNPs get together and stay together on > one piece of DNA. Maybe the more important question is how they got > together since the rate of crossover within a 128-kb segment would be only > about 0.13 cM, or 0.0013 per generation. By the way this piece of DNA > seems to be pretty old from 1000 Genome frequency data for various > populations. The highest frequency by far, about 0.14, is in the South > Asian group, with European and East Asian frequencies being about 0.02, and > the African and American Indian about 0.003 and 0-0.0013, respectively. The > low African frequency is reminiscent of the Neanderthal introgression of > about 50,000 years ago, as I recall. Could this be something like that or > indeed one of the pieces of Neanderthal DNA itself? > > Hope to hear from someone more knowledgeable than myself about this ( > Ann, Greg, Thomas, others?) >
Ian, I really appreciate you continuing to post these additions. Roberta Estes -----Original Message----- From: genealogy-dna-bounces@rootsweb.com [mailto:genealogy-dna-bounces@rootsweb.com] On Behalf Of Ian Logan via Sent: Wednesday, November 11, 2015 4:31 AM To: genealogy-dna@rootsweb.com Subject: [DNA] 2 new 'ancient' mtDNA sequences from 'Beringia' on GenBank (08-NOV-2015) List Two new mtDNA sequences from ancient Beringian remains have appeared on the GenBank database. They belong to Haplogroups B2 & C1b and accompany the paper: "Two contemporaneous mitogenomes from terminal Pleistocene burials in eastern Beringia." Tackney JC, Potter BA, et al. Proc Natl Acad Sci U S A. 2015 Oct 26. pii: Abstract below. As usual I have added the sequecnes to my 'Checker' program to ensure accuacy of transcription. Ian www.ianlogan.co.uk ------------------------ Abstract Pleistocene residential sites with multiple contemporaneous human burials are extremely rare in the Americas. We report mitochondrial genomic variation in the first multiple mitochondrial genomes from a single prehistoric population: two infant burials (USR1 and USR2) from a common interment at the Upward Sun River Site in central Alaska dating to ∼11,500 cal B.P. Using a targeted capture method and next-generation sequencing, we determined that the USR1 infant possessed variants that define mitochondrial lineage C1b, whereas the USR2 genome falls at the root of lineage B2, allowing us to refine younger coalescence age estimates for these two clades. C1b and B2 are rare to absent in modern populations of northern North America. Documentation of these lineages at this location in the Late Pleistocene provides evidence for the extent of mitochondrial diversity in early Beringian populations, which supports the expectations of the Beringian Standstill Model. --------------------- KT891989(Beringia-ancient) Tackney Haplogroup C1b 08-NOV-2015 A73G A249- A263G A290- A291- T489C A493G C522- A523- A750G A1438G A2706G C3107N T3552A A4715G A4769G C7028T C7196A G8584A A8701G A8860G T9540C A9545G A10398G C10400T T10873C G11719A G11914A C12705T A13263G T14318C C14766T T14783C G15043A G15301A A15326G A15487T C16223T C16292T T16298C T16325C C16327T KT891990(Beringia-ancient) Tackney Haplogroup B2 08-NOV-2015 A73G A263G G499A A750G A827G A1438G A2706G C3107N A4769G G4820A T4977C C6473T C7028T C8281- C8282- C8283- C8284- C8285- T8286- C8287- T8288- A8289- A8860G T9950C C11177T G11719A G13590A C14766T A15326G C15535T A16182- A16183- T16189C 16193.1C 16193.2C T16217C T16519C ------------------------------- To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message
List The remainder of the sequences. Ian ---------------------- KT819245(Morocco) Hernandez Haplogroup L1b1a 08-NOV-2015 A73G T152C C182T G185T T195C G247A A263G 309.1C 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A C7867T A8248G C8468T C8655T A8701G A8860G T9540C A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14178C A14203G G14560A C14766T A14769G T15115C A15326G T16093C T16126C C16187T T16189C C16223T C16264T C16270T C16278T T16311C T16519C KT819246(Morocco) Hernandez Haplogroup L1b1a6 08-NOV-2015 A73G T152C C182T G185T T195C G247A A263G 309.1C 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A C7867T A8248G C8468T C8655T A8701G A8860G T9540C G9755A A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14110C T14178C A14203G G14560A C14766T A14769G T15115C T15262C A15326G T16126C C16187T T16189C C16223T C16264T C16270T C16278T A16293G T16311C T16519C KT819247(Morocco) Hernandez Haplogroup L2a1k 08-NOV-2015 A73G G143A T146C T152C T195C A263G 315.1C A750G G769A G1018A A1438G T2416C A2706G C2789T C3594T A4104G A4769G G6722A C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G A8860G A9221G T9540C T10115C A10398G T10873C G11719A G11914A T11944C A12693G C12705T G13590A C13650T A13803G A14566G C14766T A15064G G15301A A15326G T15784C G16129A T16189C C16192T C16223T C16278T C16294T A16309G G16390A T16519C KT819248(Morocco) Hernandez Haplogroup L2a1c 08-NOV-2015 A73G G143A T146C T152C T195C A263G 309.1C 315.1C C522- A523- A750G G769A G1018A A1438G T2416C A2706G C2789T G3010A C3594T A4104G A4769G C6164T A6663G C7028T T7175C C7256T C7274T G7521A T7679C A7771G G8065A G8206A A8701G A8860G A9221G C9320T T9540C T10115C A10398G T10873C G11719A G11914A T11944C A12693G C12705T T13488C G13590A C13650T A13803G A14002G A14566G C14766T G15301A A15326G T15784C C16223T C16278T C16294T G16390A T16519C KT819249(Morocco) Hernandez Haplogroup L3e5a 08-NOV-2015 A73G C150T A263G 315.1C T398C C522- A523- A1438G T2352C A2706G A4769G C7028T G8392A A8701G A8860G T9540C A10398G A10819G T10873C G11719A C12705T G13317A T14212C C14766T G15301A A15326G A16041G C16223T T16519C KT819250(Morocco) Hernandez Haplogroup U6a8a 08-NOV-2015 A73G G143A A263G 309.1C 315.1C A1438G A2706G A3348G A4769G C7028T G7805A C8062T C8282T A8860G G10172A A11467G C11539T G11719A A12308G G12372A A14179G C14766T A15326G T16172C A16183- T16189C 16193.1C A16219G C16278T KT819251(Morocco) Hernandez Haplogroup L1b1a8 08-NOV-2015 A73G T146C T152C C182T G185T T195C G247A A263G 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T A7298G T7389C G7521A C7867T A8248G C8468T C8655T A8701G A8860G T9540C A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14178C A14203G G14560A C14766T A14769G T15115C A15326G T16126C C16187T T16189C C16223T C16264T C16278T A16293G T16311C T16519C KT819252(Morocco) Hernandez Haplogroup L1b1a6 08-NOV-2015 A73G T152C C182T G185T T195C C198T G247A A263G 309.1C 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A C7867T A8248G C8468T C8655T A8701G A8860G T9540C G9755A A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14110C T14178C A14203G G14305A G14560A C14766T A14769G T15115C A15326G A15903G T16093C T16126C T16172C C16187T T16189C C16223T C16264T C16270T C16278T A16293G T16311C T16519C KT819253(Morocco) Hernandez Haplogroup L2a1k 08-NOV-2015 A73G G143A T146C T152C T195C A263G 315.1C A750G G769A G1018A A1438G T2416C A2706G C2789T C3594T A4104G A4769G G6722A C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G A8860G A9221G T9540C T10115C A10398G T10873C G11719A G11914A T11944C A12693G C12705T G13590A C13650T A13803G A14566G C14766T G15301A A15326G T15784C A16041G G16129A T16189C C16192T C16223T C16278T C16294T A16309G G16390A KT819254(Morocco) Hernandez Haplogroup L2a1k 08-NOV-2015 A73G G143A T146C T152C T195C A263G 315.1C A750G G769A G1018A A1438G T2416C A2706G C2789T C3594T A4104G A4769G G6722A C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G A8860G A9221G T9540C T10115C A10398G T10873C G11719A G11914A T11944C A12693G C12705T G13590A C13650T A13803G A14566G C14766T G15301A A15326G T15784C A16041G G16129A T16189C C16192T C16223T C16278T C16294T A16309G G16390A KT819255(Morocco) Hernandez Haplogroup L2e 08-NOV-2015 A73G T146C T152C C182T T199C A263G 309.1C 309.2C 315.1C A479G G719A A750G G769A G1018A G1211A A1438G T2416C A2706G A3537G C3594T A4104G T4205C G4481A G4512A A4562G A4769G A5069T C5228T T6014C G6261A C7028T C7256T G7521A G8206A T8383C C8522T A8701G A8860G A9221G A9377G G9380A T9540C A9635G C9971T T10115C A10398G T10873C G11719A A11930G T11935C T12189C T12441C C12705T G13590A C13650T G13708A T14299C C14766T G15301A A15326G T15697C G15734A T15889C G15930A C16111A G16145A C16184T T16189C C16223T C16239T C16259T C16278T C16355T G16390A A16399G C16400T T16519C KT819256(Morocco) Hernandez Haplogroup L3b1 08-NOV-2015 A73G C151T T152C A263G 315.1C C522- A523- A750G A1438G T2071C A2706G C3450T A4769G G5417A G5773A T6221C C7028T A8701G A8860G T9174C C9449T T9540C A10086G G10373A A10398G T10601C T10873C A11380G G11719A C12705T A13105G C13914A C14766T G15301A A15311G G15314A A15326G A15824G T15940- T16124C C16223T C16234T C16278T T16362C T16409C T16519C KT819257(Morocco) Hernandez Haplogroup L3b1a9 08-NOV-2015 A73G T152C A263G 315.1C C522- A523- A750G A1438G A2706G C3450T A4769G G5773A T6221C C7028T A8701G A8860G C9449T T9540C A10086G G10373A A10398G T10873C A11002G G11719A C12705T A13105G C13914A C14766T G15301A A15311G A15326G A15824G T15940- A16051G C16223T C16256T C16278T T16362C T16519C KT819258(Morocco) Hernandez Haplogroup L1b1a3 08-NOV-2015 A73G A263G 309.1C 315.1C A503G C522- A523- A750G T1193C A1438G A2706G C3450T A4769G G5773A T6221C C7028T G8251A A8701G A8860G C9449T T9540C A10086G G10373A A10398G T10873C A11002G G11719A C12705T A13105G C13914A A13933G C14766T G15301A A15311G A15326G A15824G T15944- T16124C C16223T C16278T T16311C T16362C T16519C KT819259(Morocco) Hernandez Haplogroup L3b1a5 08-NOV-2015 A73G T152C A263G 309.1C 315.1C T480C G499A C522- A523- A750G A1438G T1780C A2706G C3450T A4769G T5063C G5773A T6221C C7028T A8701G A8860G C9449T T9540C T9615C A10086G G10373A A10398G A10700G T10873C A11002G G11719A A12612G C12705T A13105G C13914A C14766T G15301A A15311G A15326G A15824G T15940- T16124C C16223T C16278T A16293G T16362C T16519C KT819260(Morocco) Hernandez Haplogroup L3e2b 08-NOV-2015 A73G C150T T152C T195C A263G 315.1C A750G A1438G A1676G T2352C A2706G G3834A A4769G T6956C C7028T A8701G T8848C A8860G T9540C A10398G A10819G T10873C G11719A C12705T A13263G T14212C C14766T G14905A G15301A A15326G T16172C A16182- A16183- T16189C 16193.1C 16193.2C C16223T C16320T T16519C KT819261(Morocco) Hernandez Haplogroup L3e2b 08-NOV-2015 A73G C150T T152C T195C A263G 315.1C A750G A1438G T2352C T2483C A2706G G3277A A4769G A4811G C5899- C7028T A8701G A8860G A9377G T9540C A10398G A10819G T10873C G11719A G12406A C12432T C12705T T14212C C14766T G14905A G15301A A15326G T16172C A16183- T16189C 16193.1C C16223T C16320T T16519C KT819262(Morocco) Hernandez Haplogroup L3e2b1a2 08-NOV-2015 A73G C150T T152C A263G 309.1C 315.1C T398C C522- A523- A1438G T2352C A2706G A4769G C7028T G8392A A8701G A8860G C9102T T9540C A10398G A10819G T10873C G11719A C12705T G13317A C13934T T14212C C14766T G15301A A15326G A16041G C16223T T16519C KT819263(Morocco) Hernandez Haplogroup L3e5a1 08-NOV-2015 A73G C150T T152C A263G 315.1C T398C C522- A523- A1438G T2352C A2706G A2833G A4769G C7028T G8392A A8701G A8860G T9540C A10398G A10819G T10873C G11719A C12705T G13317A C14073T T14212C C14766T G15301A A15326G A16041G C16188T C16223T T16519C KT819264(Morocco) Hernandez Haplogroup M1a1b2 08-NOV-2015 A73G T195C G207A A263G 315.1C T489C A750G A813G G930A A1438G A1820G A2706G G3705A A4769G G6446A T6671C T6680C C7028T G7853A A8537G A8701G A8860G T9540C A10398G C10400T T10873C G11719A C12346T C12403T C12705T A12950C T14110C C14766T T14783C T14788C G15043A G15301A A15326G G15497A G16129A T16189C C16223T T16249C T16311C T16359C T16519C KT819265(Morocco) Hernandez Haplogroup U6a7a1 08-NOV-2015 A73G T152C A263G 315.1C A750G T794A T1193C A1438G A1692T A2706G A3348G A4769G A5120G G5471A C7028T G7805A T8473C A8860G A11467G G11719A A12308G G12372A A14179G C14766T G15043A A15326G T15530C C15632T T16172C A16219G C16278T KT819266(Morocco) Hernandez Haplogroup U6a7c1 08-NOV-2015 A73G A263G 309.1C 315.1C A750G A1438G A2706G A3348G A4769G C7028T G7337A G7805A A8860G A11467G G11719A A12308G G12372A C14766T G15043A A15326G T16172C A16182- A16183- T16189C 16193.1C 16193.2C A16219G C16278T
List The second batch of 20 sequences. Ian --------------------------- KT819225(Spain) Hernandez Haplogroup L3d1b1 08-NOV-2015 A73G C150T T152C A263G 309.1C 315.1C C522- A523- A750G T921C A1438G A2706G C3459T A4769G G5046A G5147A A5605G A6272G T6680C T6842C C7028T A7424G T8618C A8701G A8860G A9156G T9540C A10398G T10873C G11719A C12705T A13105G T13886C C14284T C14766T G15301A A15326G T16093C T16124C C16223T T16311C KT819226(Spain) Hernandez Haplogroup L3d3b 08-NOV-2015 A73G T152C A263G 315.1C C522- A523- A750G T921C G1393A A1438G G1719A A2706G T4688C A4769G G5147A G5773A G6722A C7028T T7389C A7424G T8277C T8279C T8618C A8701G A8860G T9540C A10398G T10873C G11719A C11779T A12046T C12705T A13105G T13752C T13886C C14284T C14766T A15061G G15301A A15326G T16124C C16223T KT819227(Spain) Hernandez Haplogroup L3h1b1a 08-NOV-2015 A73G T152C A189C C194T T195C A263G 309.1C 315.1C C522- A523- A750G A1438G G1719A A2706G T3777C A4388G A4769G C5300T A6359G C7028T A7717G T7861C G8152A A8701G A8860G T9509C T9540C G9575A A10044G A10398G T10873C A11590G G11719A C12705T G14410A C14766T G15301A A15326G C16179T C16223T T16243C C16256A A16284G T16311C C16320T T16519C KT819228(Spain) Hernandez Haplogroup L3x2b1 08-NOV-2015 A73G C150T C194T A200G A249- A263G 315.1C C494T T650C A750G A1438G A2706G G3483A A4769G A5656G 5899.1C A6401G C7028T A7933G A8158G T8311C G8584A A8701G A8817G A8860G A9254G T9540C A9941G A10398G A10819G T10873C G11719A C12705T G13708A C14766T G15301A A15326G T15519C A15758G G15928A C16169T C16193T T16195C C16223T T16243C C16261T KT819229(Spain) Hernandez Haplogroup M1a2a1 08-NOV-2015 A73G T152C T195C A263G 315.1C 315.2C 315.3C T489C G513A A750G A813G A1438G A2706G A4769G G6446A T6671C T6680C C7028T A8701G A8860G T9540C A10398G C10400T T10873C G11719A C12403T C12705T A12950C T14110C A14127G C14766T T14783C G15043A G15172A G15301A A15326G G15884A G16129A A16183- T16189C 16193.1C C16223T T16249C T16311C T16519C KT819230(Spain) Hernandez Haplogroup M1a3b 08-NOV-2015 A73G T195C A263G 309.1C 309.2C 315.1C T489C A750G A813G A1438G A2706G A4769G G6446A T6671C T6680C C7028T A8701G A8860G G9039A T9540C A10398G C10400T C10475T T10873C G11719A C12403T T12414C C12705T A12950C A13637G T14110C C14766T T14783C G15043A G15301A A15326G G15930A G16129A A16182- A16183- T16189C 16193.1C 16193.2C T16249C T16311C T16519C KT819231(Spain) Hernandez Haplogroup M1b2c 08-NOV-2015 A73G T195C A263G 309.1C 315.1C T489C A750G G1007A A1438G A2706G G3736A A4769G G6446A T6680C C7028T T7258C C8472T A8512G A8701G A8860G T9540C A10398G C10400T T10873C A10895G G11719A C12403T C12705T A12950C C12968T T13111C T14110C C14766T T14783C G15043A G15301A A15326G G16129A A16182- A16183- T16189C 16193.1C 16193.2C C16223T T16249C T16311C A16399G T16519C KT819232(Spain) Hernandez Haplogroup U6a6b1 08-NOV-2015 A73G A263G 315.1C A750G A1438G A2706G A3348G A4769G G5471A C7028T T7391C G7805A C8407A G8557C A8860G A11084G A11467G G11719A A12308G G12372A G12501A G12618A C13440T C13984T A14179G C14766T A15326G T16172C A16219G C16278T C16290T KT819233(Spain) Hernandez Haplogroup U6a1b2 08-NOV-2015 A73G T195C A263G 309.1C 315.1C A750G A1438G A2706G A3348G A4769G G6018A C7028T G7805A A8860G G10364A A11467G G11719A A12308G G12372A A14179G C14562T C14766T A14927G A15326G T16172C A16219G A16235G C16278T C16294T KT819234(Spain) Hernandez Haplogroup U6a3b 08-NOV-2015 A73G T146C T152C G185A A188G A263G 309.1C 309.2C 315.1C A750G G1211A A1438G A2706G A3348G A4769G C7028T G7805A A8860G C11268T A11467G G11719A A12308G G12372A C13431T A14179G C14766T A15326G A15634G C15790T T16172C C16179T A16183- T16189C 16193.1C A16219G C16278T KT819235(Spain) Hernandez Haplogroup U6a7a1 08-NOV-2015 A73G T152C A263G 315.1C C522- A523- A750G T794A T1193C A1438G A1692T A2706G A3348G A4769G A5120G G5471A C7028T G7805A T8167C T8473C A8860G A11467G G11719A A12308G G12372A A14179G C14766T G15043A A15326G T15530C C15632T T16172C A16219G C16278T KT819236(Spain) Hernandez Haplogroup U6b 08-NOV-2015 A73G A259G A263G 315.1C A508G C522- A523- A750G A1438G A2706G A3348G A4225G A4769G C7028T A8860G G9438A A11467G G11719A A12308G G12372A C14766T A15326G T15601C T16172C A16219G T16311C T16519C KT819237(Morocco) Hernandez Haplogroup L1b1a6 08-NOV-2015 A73G T152C C182T G185T T195C G247A A263G 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4164G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A C7867T A8248G C8468T C8655T A8701G C8835T A8860G T9540C G9755A A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14110C T14178C A14203G G14560A C14766T A14769G T15115C A15326G C16187T T16189C C16223T C16264T C16270T C16278T A16293G T16311C T16519C KT819238(Morocco) Hernandez Haplogroup L2a1 08-NOV-2015 A73G G143A T146C T152C T195C A263G 315.1C A750G G769A G1018A A1438G C1628T T2416C A2706G C2789T C3594T A4104G A4769G G5460A C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G A8860G A9221G T9540C T10115C A10398G T10873C G11719A G11914A T11944C A12693G C12705T G13590A C13623T C13650T A13803G A14566G C14766T G15301A A15326G T15747C T15784C T16093C T16189C C16223T C16278T C16294T A16309G G16390A T16519C KT819239(Morocco) Hernandez Haplogroup L2b1a 08-NOV-2015 A73G C150T T152C C182T T195C C198T T204C G207A G260A A263G 309.1C 315.1C C418T C522- A523- A750G G769A G1018A A1438G G1442A C1706T C2332T A2358G T2416C A2706G C3594T A4104G A4158G T4370C A4767G A4769G C5027T C5331A T5814C G6026A C6713T C7028T C7256T G7521A T7624A C8080T G8206A G8387A A8701G A8860G T8939C A9221G T9540C G9663A T10115C A10398G T10828C T10873C A11654G G11719A T11944C G12236A C12705T T12793C A12948G G13590A C13650T T13814C C13924T C14003T A14059G C14766T G15110A G15217A G15301A A15326G T16093C C16114A G16129A C16148T G16213A C16223T C16278T C16355T T16362C T16368C G16390A KT819240(Morocco) Hernandez Haplogroup L2b1a2 08-NOV-2015 A73G C150T T152C C182T T195C C198T A263G 315.1C C418T C522- A523- 590.1A A750G G769A G1018A A1118G A1438G G1442A C1706T C2332T A2358G T2416C A2706G C3594T A4104G A4158G T4370C A4767G A4769G C5027T C5331A T5814C G6026A C6713T C7028T C7256T G7521A A7569G T7624A C8080T G8206A G8387A A8701G A8860G A9221G T9540C T10115C A10398G T10828C T10873C G11719A T11944C G12007A G12236A C12705T A12948G G13590A C13650T C13924T A14059G T14180C C14766T G15110A G15217A G15301A A15326G C16114A G16129A G16213A C16223T C16278T C16355T T16362C G16390A KT819241(Morocco) Hernandez Haplogroup L3e5 08-NOV-2015 A73G C150T A263G 309.1C 315.1C T398C C522- A523- A1438G T2352C A2706G A4769G C7028T G8392A A8701G A8860G T9540C A10398G A10819G T10873C G11719A C12705T T14212C C14766T G15301A A15326G A16041G C16223T C16355T T16519C KT819242(Morocco) Hernandez Haplogroup L3e5a 08-NOV-2015 A73G C150T T152C C242T A263G 309.1C 315.1C T398C C522- A523- A1438G T2352C A2706G A4769G C7028T G8392A A8701G A8860G T9540C A10398G C10751T A10819G T10873C G11719A C12705T G13317A C13934T T14212C C14766T T14798C G15301A A15326G A16041G T16124C C16223T T16519C KT819243(Morocco) Hernandez Haplogroup U6a7a1 08-NOV-2015 A73G T152C A263G 315.1C A750G T794A T1193C A1438G A1692T A2706G A3348G A4769G A5120G G5471A C7028T G7805A T8473C A8860G A9389G A11467G G11719A A12308G G12372A A14179G C14766T G15043A A15326G T15530C C15632T T16172C A16219G C16278T KT819244(Morocco) Hernandez Haplogroup L1b1a 08-NOV-2015 A73G T152C C182T G185T T195C G247A A263G 309.1C 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A C7867T A8248G C8468T C8655T A8701G A8860G T9540C A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14178C A14203G G14560A C14766T A14769G T15115C A15326G T16093C T16126C C16187T T16189C C16223T C16264T C16270T C16278T T16311C T16519C
List A set of 62 mtDNA sequences from Spanish and Morrocan subjects has appeared on theGenBank database. The sequences accompany a paper (abstract below): "Early Holocenic and Historic mtDNA African Signatures in the Iberian Peninsula: The Andalusian Region as a Paradigm." Hernández CL, Soares P, et al. PLoS One. 2015 Oct 28;10(10) and a free download at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139784 The sequences belong to a variety of L, M1 & U6 Haplogroups. As usual I have added the sequences to my 'Checker' program to ensure accuracy of transcription. Ian www.ianlogan.co.uk -------------------------- Abstract Determining the timing, identity and direction of migrations in the Mediterranean Basin, the role of "migratory routes" in and among regions of Africa, Europe and Asia, and the effects of sex-specific behaviors of population movements have important implications for our understanding of the present human genetic diversity. A crucial component of the Mediterranean world is its westernmost region. Clear features of transcontinental ancient contacts between North African and Iberian populations surrounding the maritime region of Gibraltar Strait have been identified from archeological data. The attempt to discern origin and dates of migration between close geographically related regions has been a challenge in the field of uniparental-based population genetics. Mitochondrial DNA (mtDNA) studies have been focused on surveying the H1, H3 and V lineages when trying to ascertain north-south migrations, and U6 and L in the opposite direction, assuming that those lineages are good proxies for the ancestry of each side of the Mediterranean. To this end, in the present work we have screened entire mtDNA sequences belonging to U6, M1 and L haplogroups in Andalusians-from Huelva and Granada provinces-and Moroccan Berbers. We present here pioneer data and interpretations on the role of NW Africa and the Iberian Peninsula regarding the time of origin, number of founders and expansion directions of these specific markers. The estimated entrance of the North African U6 lineages into Iberia at 10 ky correlates well with other L African clades, indicating that U6 and some L lineages moved together from Africa to Iberia in the Early Holocene. Still, founder analysis highlights that the high sharing of lineages between North Africa and Iberia results from a complex process continued through time, impairing simplistic interpretations. In particular, our work supports the existence of an ancient, frequently denied, bridge connecting the Maghreb and Andalusia. ------------------ KT819205(Spain) Hernandez Haplogroup L1b1a12a 08-NOV-2015 A73G T152C C182T G185T T195C C198T G247A A263G 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A G1462A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A C7867T A8248G C8468T C8655T A8701G A8860G T9540C A10398G G10688A T10810C T10873C A11002G G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14178C A14203G G14560A C14766T A14769G T15115C A15326G T16126C C16187T T16189C C16223T C16264T C16270T C16278T A16293G T16311C C16400T T16519C KT819206(Spain) Hernandez Haplogroup L1b1a6 08-NOV-2015 A73G C151T T152C C182T G185T T195C G247A A263G 315.1C A357G C522- A523- G709A T710C A750G G769A T825A G1018A T1738C T2352C A2706G G2758A A2768G T2885C T3308C C3594T G3666A G3693A A4104G A4769G A5036G G5046A T5393C T5655C C6548T T6827C A6989G C7028T A7055G A7146G C7256T T7389C G7521A G7805A C7867T A8248G C8468T C8655T A8701G A8860G T9540C G9755A A10398G G10688A T10810C T10873C G11719A T12519C C12705T A13105G C13506T C13650T T13789C C13880A T14110C T14178C A14203G G14560A C14766T A14769G T15115C A15326G T16126C C16187T T16189C C16223T C16264T C16270T C16278T A16293G T16311C T16519C KT819207(Spain) Hernandez Haplogroup L2a1 08-NOV-2015 A73G G143A T146C T152C T195C A263G 309.1C 315.1C A750G G769A G1018A A1438G T2416C A2706G C2789T C3594T A4104G A4769G G5460A C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G A8860G A9221G T9540C T10115C A10398G T10873C G11719A G11914A T11944C A12693G C12705T G13590A C13623T C13650T A13803G A14566G C14766T A15218G G15301A A15326G T15784C T16093C T16189C C16192T C16223T C16260T C16278T C16294T A16309G G16390A T16519C KT819208(Spain) Hernandez Haplogroup L2a1c6 08-NOV-2015 A73G G143A T146C T152C A189G T195C A263G 309.1C 315.1C C522- A523- A750G G769A G1018A A1438G T2416C A2706G C2789T G3010A C3594T A4104G A4164G A4769G A6663G C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G A8860G C9201T A9221G T9540C T10115C A10398G T10873C C10954T G11719A G11914A T11944C A12693G C12705T G13590A C13650T A13803G A14566G C14766T G15301A A15326G T15784C C16169T C16223T C16239T C16278T C16294T A16309G G16390A KT819209(Spain) Hernandez Haplogroup L2b1a 08-NOV-2015 A73G C150T T152C C182T T195C C198T T204C A263G 315.1C C418T C522- A523- A750G G769A G1018A A1438G G1442A C1706T C2332T A2358G T2416C A2706G C3594T A4104G A4158G T4370C A4767G A4769G C5027T G5231A C5331A T5814C G6026A A6131G C6713T C7028T G7119A C7256T G7521A T7624A C8080T G8206A G8387A T8419C A8701G A8860G A9221G T9540C T10115C A10398G T10828C T10873C G11719A T11944C G12236A C12705T A12948G G13590A C13650T C13924T A14059G G14569A C14766T G15110A G15217A G15301A A15326G C16114A G16129A G16213A C16223T C16278T C16294T C16355T T16362C G16390A KT819210(Spain) Hernandez Haplogroup L2b3a 08-NOV-2015 A73G T146C C150T T152C C182T T195C C198T T204C G207A A263G 315.1C A750G G769A G1018A A1438G G1442A C1706T C2332T A2358G T2416C A2706G C3594T A4104G A4158G C4185T T4370C A4767G A4769G C5027T C5331A G5744A T5814C C6713T C7028T C7256T G7521A T7624A C8080T G8206A G8387A A8701G A8860G A8925G A9221G T9540C T10115C A10398G T10873C G11719A T11944C G12236A C12705T A12948G G13590A C13650T A14059G G14544A C14766T G15110A G15217A A15236G G15301A G15928A 15944.1T T16093C C16114A G16129A G16213A C16223T T16271C C16278T G16390A KT819211(Spain) Hernandez Haplogroup L3f1b1 08-NOV-2015 A73G A189G A200G A263G 315.1C A750G A1438G T1822C A2706G T3396C T4218C A4769G C5601T C7028T C7819A A8527G A8701G A8860G C8932T T9540C T9950C A10398G T10873C G11440A G11719A C12705T C14766T A14769G G15301A A15326G T15514C T15940- T16209C C16223T C16292T C16295T T16311C T16519C KT819212(Spain) Hernandez Haplogroup M1a1b1 08-NOV-2015 A73G T195C A263G 309.1C 309.2C 315.1C T489C A750G A813G G930A A1438G A2706G G3705A A4769G G6446A T6671C T6680C C7028T G7853A A8701G A8860G T9540C A10398G C10400T T10873C G11719A T11809C C12346T C12403T C12705T A12950C T14110C C14766T A14769G T14783C G15043A G15301A A15326G G16129A A16183- T16189C 16193.1C C16223T T16249C T16311C T16359C T16519C KT819213(Spain) Hernandez Haplogroup U6a1a1a 08-NOV-2015 A73G A263G 309.1C 315.1C C522- A523- A750G A1438G A2706G A3348G C3969T T4172A A4769G C7028T G7805A A8860G A11467G G11719A C11938T A12308G G12372A A14179G C14766T A14927G A15326G T16172C A16183- T16189C 16193.1C A16219G C16239T C16278T KT819214(Spain) Hernandez Haplogroup U6a1a1a 08-NOV-2015 A73G A263G 309.1C 315.1C A750G A1438G A2706G A3348G C3969T T4172A A4769G C7028T G7805A A8860G T9185G A11467G G11719A C11938T A12308G G12372A A14179G C14766T A14927G A15326G T16093C T16172C A16183- T16189C 16193.1C A16219G C16239T C16278T C16291T KT819215(Spain) Hernandez Haplogroup U6a1a1a 08-NOV-2015 A73G A263G 309.1C 315.1C A750G A1438G A2706G A3348G C3969T T4172A A4769G C7028T G7805A A8860G T9185G A11467G G11719A C11938T A12308G G12372A A14179G C14766T A14927G A15326G T16172C A16183- T16189C 16193.1C A16219G C16239T C16278T C16291T KT819216(Spain) Hernandez Haplogroup U6a3b 08-NOV-2015 A73G T146C T152C G185A A188G A263G 309.1C 315.1C A750G G1211A A1438G A2706G A3348G A4769G C7028T G7805A A8860G C11268T A11467G G11719A A12308G G12372A C13431T C14142A A14179G C14766T A15326G A15634G C15790T T16172C A16183- T16189C 16193.1C A16219G C16278T KT819217(Spain) Hernandez Haplogroup U6a3b 08-NOV-2015 A73G T146C T152C G185A A188G A263G 309.1C 315.1C A750G G1211A A1438G A2706G A3348G A4769G C7028T G7805A A8860G C11268T A11467G G11719A A12308G G12372A C13431T C14142A A14179G C14766T A15326G A15634G C15790T T16172C A16183- T16189C 16193.1C A16219G C16278T KT819218(Spain) Hernandez Haplogroup U6a3b1 08-NOV-2015 A73G T146C T152C G185A A188G A263G 309.1C 315.1C A750G G1211A A1438G A2706G A3348G A4769G C7028T G7805A A8860G C11268T A11467G G11719A A12308G G12372A C13431T A14179G C14766T A15326G A15634G C15790T T16172C A16183- T16189C 16193.1C A16219G C16278T T16311C KT819219(Spain) Hernandez Haplogroup U6a3b1 08-NOV-2015 A73G T146C T152C G185A A188G A263G 309.1C 315.1C A750G G1211A A1438G A2706G A3348G A4769G C7028T G7805A A8860G C11268T A11467G G11719A A12308G G12372A C13431T A14179G C14766T A15326G A15634G C15790T T16172C A16183- T16189C 16193.1C A16219G C16278T T16311C KT819220(Spain) Hernandez Haplogroup U6a7a1b 08-NOV-2015 A73G C150T T152C A263G 315.1C A750G T794A T1193C A1438G A1692T A2706G A3348G A4769G A5120G G5471A C7028T G7805A T8473C A8860G A11467G G11719A A12308G G12372A A14179G C14766T G15043A A15326G T15530C C15632T T16172C A16219G C16278T KT819221(Spain) Hernandez Haplogroup U5c2b 08-NOV-2015 A73G C150T C194T A263G 315.1C C437T C522- A523- A750G C793T A1438G A2706G A3348G G3688C A4769G A4965G T5081C C6340T C7028T A8860G C11013T A11467G G11719A A12076G A12308G G12372A T13879C T14308C C14766T A15244G A15326G C16169T T16172C T16189C KT819222(Spain) Hernandez Haplogroup U6d3a 08-NOV-2015 A73G A263G 315.1C A750G A1438G A2706G A3348G T4336C A4769G C7028T A8860G A10397G A11467G G11719A A11947G A12308G G12372A G12501A A12530G A14518G C14766T A15326G T16172C C16174T C16188T A16219G T16311C KT819223(Spain) Hernandez Haplogroup Ud63a 08-NOV-2015 A73G A263G 315.1C A750G A1438G A2706G A3348G T4336C A4769G C7028T A8860G A10397G A11467G G11719A A11947G A12308G G12372A G12501A A12530G A14518G C14766T A15326G T16172C C16174T C16188T A16219G T16311C KT819224(Spain) Hernandez Haplogroup L2a1b 08-NOV-2015 A73G G143A T146C T152C T195C A263G 309.1C 309.2C 315.1C A750G G769A G1018A A1438G T2416C A2706G C2789T C3594T A4104G A4769G C7028T T7175C C7256T C7274T G7521A A7771G G8206A A8701G G8838A A8860G A9221G T9540C T10115C G10143A A10398G T10873C A11650G G11719A G11914A T11944C G12406A A12693G C12705T G13590A C13650T A13803G A14566G C14766T G15301A A15326G T15784C T16093C G16129A T16189C C16223T C16278T C16294T A16309G G16390A
List Two new mtDNA sequences from ancient Beringian remains have appeared on the GenBank database. They belong to Haplogroups B2 & C1b and accompany the paper: "Two contemporaneous mitogenomes from terminal Pleistocene burials in eastern Beringia." Tackney JC, Potter BA, et al. Proc Natl Acad Sci U S A. 2015 Oct 26. pii: Abstract below. As usual I have added the sequecnes to my 'Checker' program to ensure accuacy of transcription. Ian www.ianlogan.co.uk ------------------------ Abstract Pleistocene residential sites with multiple contemporaneous human burials are extremely rare in the Americas. We report mitochondrial genomic variation in the first multiple mitochondrial genomes from a single prehistoric population: two infant burials (USR1 and USR2) from a common interment at the Upward Sun River Site in central Alaska dating to ∼11,500 cal B.P. Using a targeted capture method and next-generation sequencing, we determined that the USR1 infant possessed variants that define mitochondrial lineage C1b, whereas the USR2 genome falls at the root of lineage B2, allowing us to refine younger coalescence age estimates for these two clades. C1b and B2 are rare to absent in modern populations of northern North America. Documentation of these lineages at this location in the Late Pleistocene provides evidence for the extent of mitochondrial diversity in early Beringian populations, which supports the expectations of the Beringian Standstill Model. --------------------- KT891989(Beringia-ancient) Tackney Haplogroup C1b 08-NOV-2015 A73G A249- A263G A290- A291- T489C A493G C522- A523- A750G A1438G A2706G C3107N T3552A A4715G A4769G C7028T C7196A G8584A A8701G A8860G T9540C A9545G A10398G C10400T T10873C G11719A G11914A C12705T A13263G T14318C C14766T T14783C G15043A G15301A A15326G A15487T C16223T C16292T T16298C T16325C C16327T KT891990(Beringia-ancient) Tackney Haplogroup B2 08-NOV-2015 A73G A263G G499A A750G A827G A1438G A2706G C3107N A4769G G4820A T4977C C6473T C7028T C8281- C8282- C8283- C8284- C8285- T8286- C8287- T8288- A8289- A8860G T9950C C11177T G11719A G13590A C14766T A15326G C15535T A16182- A16183- T16189C 16193.1C 16193.2C T16217C T16519C
I mentioned this segment before, but the more I study it the less I understand it. In looking at my whole-genome sequence in the region of the PRDM2 gene at locations 14026714 thru 14151574 of chromosome 1, I decided to BLAST the Build GRCh37 sequence of PRDM2 against the human genome to see if there were other similar sequences which could have caused mapping to the wrong sequence. The only similar sequence I found was an "alternate" sequence covering the same region, but with several mismatches to the GRCh37 sequence. In looking at these mismatches more closely, I found that one of my chomosome1 copies matched every one of the mismatches between the GRCh37 and "alternate" sequences. In addition, the 1000 Genomes database shows an SNP at each of these mismatch positions. Many of these SNPs, according to 1000 Genomes, have identical frequencies, indicating that they are always found together (i.e., on the same chromosome). Most of these frequencies are in the 0.03 to 0.04 area with a few as low as 0.012. In other words, they are in the "uncommon" but not "extremely rare" category. I have since extended the region of comparison and found that it extends from GRCh37 chr1 location 14000722 to location 14129498, beginning somewhat upstream of the PRDM2 gene and ending before the last small coding exon of PRDM2. This span includes 366 mismatches between the GRCh37 (or GRCh38) reference sequence and the "alternate" chr1 sequence (locations 13799083 to 13927951 of CHM1_1.1; ID: ref|NC_018912.2 <https://www.ncbi.nlm.nih.gov/nucleotide/528476670?report=genbank&log$=nuclalign&blast_rank=1&RID=3ZJ88E01113> My question is how did all of these SNPs get together and stay together on one piece of DNA. Maybe the more important question is how they got together since the rate of crossover within a 128-kb segment would be only about 0.13 cM, or 0.0013 per generation. By the way this piece of DNA seems to be pretty old from 1000 Genome frequency data for various populations. The highest frequency by far, about 0.14, is in the South Asian group, with European and East Asian frequencies being about 0.02, and the African and American Indian about 0.003 and 0-0.0013, respectively. The low African frequency is reminiscent of the Neanderthal introgression of about 50,000 years ago, as I recall. Could this be something like that or indeed one of the pieces of Neanderthal DNA itself? Hope to hear from someone more knowledgeable than myself about this ( Ann, Greg, Thomas, others?)