Regarding accents - from an Australian ear, and as I have also lived in the United States - the US accent as a whole has always struck me as having Irish origins - and since there was such a huge influx of Irish to the US I would not be at all surprised about that. That's my 2 cents worth. Merry Christmas everyone. Ann On Fri, Dec 25, 2015 at 5:51 AM, Paul Conroy via <genealogy-dna@rootsweb.com > wrote: > Murray, > > Fascinating! > > I've listened to YouTube videos of people sporting a "Newfie" accent, and > they sound very similar to Irish accents to me. > > Cheers, > Paul > > On Wednesday, December 23, 2015, Murray Bell <murraybel@msn.com> wrote: > > > I remember seeing a show on Canadian TV many years ago (probably 30) > where > > they went to a remote fishing village in Newfoundland and interviewed a > > chap whose ancestors came from St. Mullins in County Carlow Ireland. They > > also talked to residents of St. Mullins. The accent was the same & the > > expressions were the same even though many generations had passed since > > people from St. Mullins had immigrated to this remote Newfoundland > fishing > > village. This always stuck in my mind as I have been to St. Mullins and > my > > wife's grandparents are buried there. > > > > murray > > > > On Dec 19, 2015, at 6:19 AM, Paul Conroy via wrote: > > > > > Fascinating! The Irish population in Newfoundland is sourced from only > a > > > couple of specific areas: > > > 1. Waterford, Wexford and Kilkenny in the Irish South East, mostly > > > 2. Cork in the Irish South, to a lesser extent > > > > > > Both my parents show some Newfoundland relatives from SE Ireland. At > one > > > time many of these Irish people spoke Irish Gaelic (Gaeilge). In fact > the > > > last speaker of the Leinster dialect of Irish Gaelic, died in St John's > > > some years ago. The dialect had died out in Ireland decades before > that. > > > > > > Cheers, > > > Paul > > > > > > On Thursday, December 17, 2015, Ann Turner via < > > genealogy-dna@rootsweb.com <javascript:;>> > > > wrote: > > > > > >> Genetic structure is detectable based on religious background in this > > study > > >> of Newfoundland and Labrador. That could be a consequence of marrying > > >> someone with the same religion, even though the general geographic > > >> background might not be that different. > > >> > > >> > http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2015256a.html > > >> > > >> Genetic structure of the Newfoundland and Labrador population: founder > > >> effects modulate variability. > > >> > > >> Zhai G(1), Zhou J(2), Woods MO(1), Green JS(1), Parfrey P(2), Rahman > > P(2), > > >> Green RC(1). > > >> > > >> Author information: (1)Discipline of Genetics, Faculty of Medicine, > > >> Memorial University of Newfoundland, St John's, Newfoundland and > > Labrador, > > >> Canada. (2)Discipline of Medicine, Faculty of Medicine, Memorial > > >> University, St John's, Newfoundland and Labrador, Canada. > > >> > > >> The population of the province of Newfoundland and Labrador (NL) has > > been a > > >> resource for genetic studies because of its historical isolation and > > >> increased prevalence of several monogenic disorders. Controversy > remains > > >> regarding the genetic substructure and the extent of genetic > > homogeneity, > > >> which have implications for disease gene mapping. Population > > substructure > > >> has been reported from other isolated populations such as Iceland, > > Finland > > >> and Sardinia. We undertook this study to further our understanding of > > the > > >> genetic architecture of the NL population. We enrolled 494 individuals > > >> randomly selected from NL. Genome-wide SNP data were analyzed together > > with > > >> that from 14 other populations including HapMap3, Ireland, Britain and > > >> Native American samples from the Human Genome Diversity Project. Using > > >> multidimensional scaling and admixture analysis, we observed that the > > >> genetic structure of the NL population resembles that of the British > > >> population but can be divided into three clusters that correspond to > > >> religious/ethnic origins: Protestant English, Roman Catholic Irish and > > >> North American aboriginals. We observed reduced heterozygosity and an > > >> increased inbreeding coefficient (mean=0.005), which corresponds to > that > > >> expected in the offspring of third-cousin marriages. We also found > that > > the > > >> NL population has a significantly higher number of runs of > homozygosity > > >> (ROH) and longer lengths of ROH segments. These results are consistent > > with > > >> our understanding of the population history and indicate that the NL > > >> population may be ideal for identifying recessive variants for complex > > >> diseases that affect populations of European origin.European Journal > of > > >> Human Genetics advance online publication, 16 December 2015; > > >> doi:10.1038/ejhg.2015.256. > > >> > > >> ------------------------------- > > >> To unsubscribe from the list, please send an email to > > >> GENEALOGY-DNA-request@rootsweb.com <javascript:;> <javascript:;> with > > the word > > >> 'unsubscribe' without the quotes in the subject and the body of the > > message > > >> > > > > > > ------------------------------- > > > To unsubscribe from the list, please send an email to > > GENEALOGY-DNA-request@rootsweb.com <javascript:;> with the word > > 'unsubscribe' without the quotes in the subject and the body of the > message > > > > > > > > > ------------------------------- > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without > the quotes in the subject and the body of the message >

What happens if the experiment is not fully funded on Jan 7 2016? Al On Fri, Dec 25, 2015 at 7:17 AM, Al Aburto <jl25l229@gmail.com> wrote: > Thank you Bonnie & Ann ... > I have donated! Good luck with your great project Bonnie & Matthew! > Al > > On Thu, Dec 24, 2015 at 9:26 AM, Ann Turner <dnacousins@gmail.com> wrote: > >> The hyperlink in Bonnie's message included the asterisk. If you copy the >> URL and paste it into your browser, then erase the asterisk, it takes you >> to this page: >> >> >> https://experiment.com/projects/go-west-young-man-in-search-of-the-a00-haplogroup-among-peoples-of-western-cameroon >> >> Ann Turner >> >> On Wed, Dec 23, 2015 at 8:47 PM, Al Aburto via < >> genealogy-dna@rootsweb.com> wrote: >> >>> Hi Bonnie, >>> Happy Holidays. >>> The donation link didn't work for me. An error said the page didn't exist >>> ... >>> Let me know ... >>> Al >>> >> >> >> >

Thank you Bonnie & Ann ... I have donated! Good luck with your great project Bonnie & Matthew! Al On Thu, Dec 24, 2015 at 9:26 AM, Ann Turner <dnacousins@gmail.com> wrote: > The hyperlink in Bonnie's message included the asterisk. If you copy the > URL and paste it into your browser, then erase the asterisk, it takes you > to this page: > > > https://experiment.com/projects/go-west-young-man-in-search-of-the-a00-haplogroup-among-peoples-of-western-cameroon > > Ann Turner > > On Wed, Dec 23, 2015 at 8:47 PM, Al Aburto via <genealogy-dna@rootsweb.com > > wrote: > >> Hi Bonnie, >> Happy Holidays. >> The donation link didn't work for me. An error said the page didn't exist >> ... >> Let me know ... >> Al >> > > >

I have 2 $100 Big-Y coupons that expire on 12/27/2015 at 11:59 PM CT. Just send me a private mail; the first 2 will get it. Best regards, and merry Xmas, Gerrit Woertman

Hello List, I have a $75  Big Y coupon that  Expires 12/27/2015 at 11:59PM CT The first list member ,that asks for it via private e-mail will get it. Merry Xmas to all members. Best regards, Costa.Tsirigakis -----------------------------------------------------Mail.be, WebMail and Virtual Officehttp://www.mail.be

Murray, Fascinating! I've listened to YouTube videos of people sporting a "Newfie" accent, and they sound very similar to Irish accents to me. Cheers, Paul On Wednesday, December 23, 2015, Murray Bell <murraybel@msn.com> wrote: > I remember seeing a show on Canadian TV many years ago (probably 30) where > they went to a remote fishing village in Newfoundland and interviewed a > chap whose ancestors came from St. Mullins in County Carlow Ireland. They > also talked to residents of St. Mullins. The accent was the same & the > expressions were the same even though many generations had passed since > people from St. Mullins had immigrated to this remote Newfoundland fishing > village. This always stuck in my mind as I have been to St. Mullins and my > wife's grandparents are buried there. > > murray > > On Dec 19, 2015, at 6:19 AM, Paul Conroy via wrote: > > > Fascinating! The Irish population in Newfoundland is sourced from only a > > couple of specific areas: > > 1. Waterford, Wexford and Kilkenny in the Irish South East, mostly > > 2. Cork in the Irish South, to a lesser extent > > > > Both my parents show some Newfoundland relatives from SE Ireland. At one > > time many of these Irish people spoke Irish Gaelic (Gaeilge). In fact the > > last speaker of the Leinster dialect of Irish Gaelic, died in St John's > > some years ago. The dialect had died out in Ireland decades before that. > > > > Cheers, > > Paul > > > > On Thursday, December 17, 2015, Ann Turner via < > genealogy-dna@rootsweb.com <javascript:;>> > > wrote: > > > >> Genetic structure is detectable based on religious background in this > study > >> of Newfoundland and Labrador. That could be a consequence of marrying > >> someone with the same religion, even though the general geographic > >> background might not be that different. > >> > >> http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2015256a.html > >> > >> Genetic structure of the Newfoundland and Labrador population: founder > >> effects modulate variability. > >> > >> Zhai G(1), Zhou J(2), Woods MO(1), Green JS(1), Parfrey P(2), Rahman > P(2), > >> Green RC(1). > >> > >> Author information: (1)Discipline of Genetics, Faculty of Medicine, > >> Memorial University of Newfoundland, St John's, Newfoundland and > Labrador, > >> Canada. (2)Discipline of Medicine, Faculty of Medicine, Memorial > >> University, St John's, Newfoundland and Labrador, Canada. > >> > >> The population of the province of Newfoundland and Labrador (NL) has > been a > >> resource for genetic studies because of its historical isolation and > >> increased prevalence of several monogenic disorders. Controversy remains > >> regarding the genetic substructure and the extent of genetic > homogeneity, > >> which have implications for disease gene mapping. Population > substructure > >> has been reported from other isolated populations such as Iceland, > Finland > >> and Sardinia. We undertook this study to further our understanding of > the > >> genetic architecture of the NL population. We enrolled 494 individuals > >> randomly selected from NL. Genome-wide SNP data were analyzed together > with > >> that from 14 other populations including HapMap3, Ireland, Britain and > >> Native American samples from the Human Genome Diversity Project. Using > >> multidimensional scaling and admixture analysis, we observed that the > >> genetic structure of the NL population resembles that of the British > >> population but can be divided into three clusters that correspond to > >> religious/ethnic origins: Protestant English, Roman Catholic Irish and > >> North American aboriginals. We observed reduced heterozygosity and an > >> increased inbreeding coefficient (mean=0.005), which corresponds to that > >> expected in the offspring of third-cousin marriages. We also found that > the > >> NL population has a significantly higher number of runs of homozygosity > >> (ROH) and longer lengths of ROH segments. These results are consistent > with > >> our understanding of the population history and indicate that the NL > >> population may be ideal for identifying recessive variants for complex > >> diseases that affect populations of European origin.European Journal of > >> Human Genetics advance online publication, 16 December 2015; > >> doi:10.1038/ejhg.2015.256. > >> > >> ------------------------------- > >> To unsubscribe from the list, please send an email to > >> GENEALOGY-DNA-request@rootsweb.com <javascript:;> <javascript:;> with > the word > >> 'unsubscribe' without the quotes in the subject and the body of the > message > >> > > > > ------------------------------- > > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com <javascript:;> with the word > 'unsubscribe' without the quotes in the subject and the body of the message > > > >

Dear Bonnie, Thank you for keeping us informed about the progress. I've tried to lookup information about the Bangwa on Wikipedia but couldn't find anything. Only information available is on the Mbo, it's article mentions the Bangwa but there is no standalone article. Maybe someone attached to the project would like to write it, especially now from the Adam background. Just for my understanding. Is Cameroon now considered to be the birth place of Adam or is that unlikely until a higher percentage of A00 samples are found anywhere else in a location? As E1b1a is so much more present there does it mean that most A00 lines unfortunately died out? Andreas > On 24 Dec 2015, at 00:27, Bonnie Schrack via <genealogy-dna@rootsweb.com> wrote: > > Dear friends, > > Many of you remember the excitement and pride we felt when members of > the genetic genealogy community played a leading role in the discovery > of A00, the earliest branch of the Y-chromosome phylogenetic tree, when > our paper was published in early 2013. > > There was an outpouring of support when we asked for donations in summer > and fall 2013, for our proposed research project to collect more A00 > samples in Cameroon. We were fully funded for our first trips by the > community, with only modest effort. > > Then we found out how much we didn't know about getting through an > ethical review process, but eventually, we found our way to the goal -- > we were finally approved this past summer. > > Matthew immediately took to the field, and collected over 200 new > samples among the ethnic groups known to have A00 among them, the > Bangwa, and his own Mbo people. > > Testing by Thomas and Astrid Krahn at YSEQ revealed that 35 of these > samples belong to A00, a much higher percentage than anticipated! > > Most of the non-A00 samples belong to haplogroup E1b1a, and a few belong > to B2a1, A0, and other groups we have yet to determine. > > Now we're following through with the rest of the study, gathering > samples from other areas of gradually increasing distance from the A00 > epicenter, to find out the distribution and diversity of this super-rare > group. > > Matthew made another trip in October, and collected as many samples > again, from the Bamileke, and more outlying Bangwa. These now need to be > tested, for 18 STRs in every sample, and two SNPs in each sample that > has the distinctive A00 haplotype. > > This has shown, so far, that there are two main branches of A00, one > found among the Bangwa, and the other among the Mbo. One man has been > found who belongs to neither branch, and we'll be getting a full Y > sequence of his DNA, to add his branch to our tree. We'll do the same > for any other member of A00 we find who doesn't belong to one of these > two branches, or who shows notable diversity in his haplotype. And of > course, we'll be on the lookout for anyone who could possibly be a > member of a brand-new haplogroup! > > To see the current branches of the A00 tree, please go to > *http://tinyurl.com/o74vodu* > > On our next field trip, in January, Matthew will sample peoples to the > West, the Banyang and Ejagham. > > Our exciting news is that Thomas Krahn will be traveling to Cameroon in > January, and will accompany Matthew! They'll also visit villages > previously sampled, to return results to the men already tested, > something almost never done in traditional academic studies. We, as > genetic genealogists, see them as individuals, not just sources of raw > material. They are interested in learning about their paternal lineages, > and we are trying to learn as much as possible about the A00-bearing > families and their history. > > Does that sound like something you'd like to support? We're now in our > crowdfunding phase again, after two years of not asking for any of your > money. Our goal is to raise $7,655, and we've received $3,623 in > donations from 41 donors so far, leaving us $4032 to go! We only have > two weeks to make it to our goal by our deadline, Jan. 6th! > > Please help us reach it, at *http://experiment.com/A00west* > > Here are some examples of what your gift will buy: > > * For $25, you can buy three days of meals for Matthew in the field. > * For $35, you can pay for the printing of all of our Informed Consent > and Questionnaire forms that we use with each DNA donor. > * For $42, you can pay for one day's transportation in the field. > * For $50, you can pay for three days' lodging for Matthew in the field. > * For $52, you can pay for about 10% of the SNP testing of the A00 > samples that Matthew collected in October. > * For $84, you can pay the salary of the driver or translator for the > field trip. > * For $105, you can pay for the SNP testing of 1/5 of the A00 samples. > * For $132, you can pay for the SNP testing of 1/4 of the A00 samples. > * For $175, you can pay for the SNP testing of 1/3 of the A00 samples, > or the STR testing of about 5% of all the Bamileke & Bangwa samples > from October's trip. > * For $250, you can pay for the STR testing of 7% of all the samples. > * For $350, you can pay for the STR testing of 10% of all the samples. > * For $500, you can pay for the STR testing of 1/7 of all the samples. > * For $525, you can pay for the SNP testing of all of the A00 samples > from October. > * For $700, you can pay for the STR testing of 1/5 of all the samples. > * For $880, you can pay for the STR testing of 1/4 of all the samples. > * For $1200, you can pay for the STR testing of over 1/3 of all the > samples. > * For $1760, you can pay for the STR testing of half of all the samples. > * For $2000, you can pay for the STR testing of 57% of all the samples. > * For $3520, you can pay for the STR testing of all the Bamileke and > Bangwa samples collected in October. > > This year, inspiring people to donate has been a lot more challenging > than the first time. We're now really doing what we promised to do back > then, so please don't let us down! > > *http://experiment.com/A00west* is where you can contribute*. > > *There's much more yet to be done. After the trip to the West, we plan > to sample the Pygmy peoples and their neighbors, to the South and East, > where Matthew found a few A00 around the same time as he collected the > original Mbo A00 samples (those samples now belong to the Center for > Genetic Anthropology at University College London -- we have no access > to them). And we plan more full Y sequences, as I've mentioned. > > We're doing cutting-edge, basic scientific research, which will > contribute substantially to current efforts to ever more accurately date > the TMRCA of the entire tree, and all the earliest nodes within it, as > in the new paper by Barbieri et al, Refining the Y Chromosome Phylogeny > with Southern African Sequences -- see > http://biorxiv.org/content/early/2015/12/20/034983 > > But they didn't perform full Y sequences of their samples, as we've done > with our existing A00 sample from the Perry family, and will be doing > with others. All of these sequences will be available for public > access, as will the Y-STR haplotypes. > > Please help this research prosper and come to a successful conclusion, > with your generous donation at *http://experiment.com/A00west* > > Donors are entitled to advance access to our data! Just let us know > you're interested. > > Wishing you a joyful holiday season, > > Bonnie Schrack > for the A00 Cameroon Research Project > http://www.facebook.com/A00.Cameroon.Project/ > http://haplogroup-a.com > > > -- > *Farther Back We All Connect* > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message

It looks like I may have donated to Bonnie's other site for haplogroup 'A', but it will still go to a good cause. RPaine -----Original Message----- From: Ann Turner via Sent: Thursday, December 24, 2015 9:26 AM To: Al Aburto ; DNA Genealogy Mailing List Cc: Bonnie Schrack Subject: Re: [DNA] The A00 Cameroon Research Project asks for your support The hyperlink in Bonnie's message included the asterisk. If you copy the URL and paste it into your browser, then erase the asterisk, it takes you to this page: https://experiment.com/projects/go-west-young-man-in-search-of-the-a00-haplogroup-among-peoples-of-western-cameroon Ann Turner On Wed, Dec 23, 2015 at 8:47 PM, Al Aburto via <genealogy-dna@rootsweb.com> wrote: > Hi Bonnie, > Happy Holidays. > The donation link didn't work for me. An error said the page didn't exist > ... > Let me know ... > Al > ------------------------------- To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message

The hyperlink in Bonnie's message included the asterisk. If you copy the URL and paste it into your browser, then erase the asterisk, it takes you to this page: https://experiment.com/projects/go-west-young-man-in-search-of-the-a00-haplogroup-among-peoples-of-western-cameroon Ann Turner On Wed, Dec 23, 2015 at 8:47 PM, Al Aburto via <genealogy-dna@rootsweb.com> wrote: > Hi Bonnie, > Happy Holidays. > The donation link didn't work for me. An error said the page didn't exist > ... > Let me know ... > Al >

Dear Andreas, Thanks for your email! There is just one really good source of information about the Bangwa that I know of, http://www.lebialem.info/. That site collects some of the key works of scholarship on them. There are videos worth seeing on YouTube, too, such as https://youtu.be/DtSzd5qvjh8, which is long, but can be fascinating if you are a good observer. There are a lot of questions in science that are not ready to be resolved, so one can't yet say, "this is considered to be the case," as one could if it were a settled question. Thus, I cannot answer your question per se, "Is Cameroon now considered to be the birth place of Adam?" No one knows where the most recent common paternal ancestor of today's human population lived, and if anyone tells you they do know, I would look at that with a very skeptical eye. I have not seen any recent scientific paper that claims to be able to answer this question yet. The most interesting passage in a fairly recent paper, that I know of, is this, from "An unbiased resource of novel SNP markers provides a new chronology for the human Y chromosome and reveals a deep phylogenetic structure in Africa," by Rosaria Scozzari et al, Genome Research, Jan. 2014. "This geographical confinement of deep lineages is at odds with the mainly eastern African position of sites providing fossils of comparable ages (McDougall et al. 2005, but see Tattersall and Schwartz 2008). The question then becomes: when did these lineages reach central-western Africa? Two hypotheses can be put forward: first, ancient residence of A1b and A1a in eastern Africa, followed by relocating to central-western Africa and extinction in the motherland eastern Africa (possibly together with other yet unknown deep rooted branches), or second, ancient residence of A1b and A1a in central-western Africa, with loss of fossil record there. The finding of the oldest lineage recorded so far (A00, 338 kya) in Cameroon (Mendez et al. 2013), adds to our phylogeographic results in suggesting centralwestern Africa as a broad region populated by deep MSY lineages earlier than 160 kya." There may have been further interesting statements published since then, but this is the best I can offer tonight! One factor that has not been mentioned much by studies of human prehistory is that this area of Cameroon has been a refugium during periods of harsh climate change, resulting in its becoming a biodiversity hotspot, where today the rarest species of Chimpanzees and Gorillas can be found, among other animals. Thus one scenario that could be explored is that humans, like these other primates, could have ended up in Cameroon during one of the dry periods when it provided a haven. If there were other branches dating to the same or earlier period as A00, they could have been lost during those adversities. Since the model that has been gaining the most prominence is the "Braided Stream," with many small and diverse populations of early humans in Africa repeatedly separating and re-joining, it would not be as surprising that one region contributed the oldest Y lineages, while another has the oldest mtDNA, or autosomal DNA. That being said, there is much that cries out to be studied right there in Cameroon, which has some of the greatest ethnic diversity of any country in the world. Due to limited funding, we currently have no short-term plans to study the mtDNA of our samples, but I think it would be a mistake to overlook that angle in the longer term. We are in conversations with Melissa Wilson Sayres, of Arizona State, who hopes to be assisting us in analyzing the data we collect. She thinks, and I agree, that autosomal studies of these Cameroonian populations would be very important and interesting to do in the future. But new samples, collected under a distinct protocol, would have to be gathered for that project, so that we'd have even stronger mechanisms in place to protect the privacy of the sample donors, because of the far greater medical implications of autosomal variation. I would be surprised to hear of any larger concentration of A00 samples being discovered in another country, but of course there are many unstudied, remote or dangerous corners of Africa where very little is known of the people's DNA, compared with the very thorough sampling of European populations. Although I must say it is still hard for me to wrap my head around what could have happened, I would guess that the relatively tiny number of A00 living today suggests that a combination of genetic drift, and perhaps warfare, or subjugation of indigenous peoples by more aggressive warriors, with lack of ideal agricultural land and access to markets creating difficult conditions for subsistence, must have kept A00 from attaining a substantial population size, with isolation in the very rugged and inaccessible mountains of Cameroon allowing them to just barely hang on and survive over so many centuries and millennia. We often see little pockets of rare genetic groups in small, high mountain valleys, as some recent studies on the Caucasus have shown. I hope all who find this really interesting will stop to consider that we are not able to fund our research out of our own pockets, as the cost of testing hundreds of samples at even the most inexpensive prices becomes very high. This can only be done if many people come together to share the burden and make it light. We have so little time left before our deadline. As soon as the Christmas festivities allow, I hope a good number of our kind readers will stop by our website at http://experiment.com/a00west, to support this project financially, allowing us to pay our bills and gather more essential data, for the benefit of all. Bonnie -- *Farther Back We All Connect* On 12/23/2015 9:41 PM, Andreas West wrote: > Dear Bonnie, > > > Thank you for keeping us informed about the progress. I've tried to lookup information about the Bangwa on Wikipedia but couldn't find anything. Only information available is on the Mbo, it's article mentions the Bangwa but there is no standalone article. > > Maybe someone attached to the project would like to write it, especially now from the Adam background. > > Just for my understanding. Is Cameroon now considered to be the birth place of Adam or is that unlikely until a higher percentage of A00 samples are found anywhere else in a location? > > As E1b1a is so much more present there does it mean that most A00 lines unfortunately died out? > > Andreas **

Hi Bonnie, Happy Holidays. The donation link didn't work for me. An error said the page didn't exist ... Let me know ... Al On Wed, Dec 23, 2015 at 8:19 PM, Bonnie Schrack via < genealogy-dna@rootsweb.com> wrote: > Dear Andreas, > > Thanks for your email! There is just one really good source of > information about the Bangwa that I know of, http://www.lebialem.info/. > That site collects some of the key works of scholarship on them. There > are videos worth seeing on YouTube, too, such as > https://youtu.be/DtSzd5qvjh8, which is long, but can be fascinating if > you are a good observer. > > There are a lot of questions in science that are not ready to be > resolved, so one can't yet say, "this is considered to be the case," as > one could if it were a settled question. Thus, I cannot answer your > question per se, "Is Cameroon now considered to be the birth place of > Adam?" No one knows where the most recent common paternal ancestor of > today's human population lived, and if anyone tells you they do know, I > would look at that with a very skeptical eye. I have not seen any recent > scientific paper that claims to be able to answer this question yet. > > The most interesting passage in a fairly recent paper, that I know of, > is this, from "An unbiased resource of novel SNP markers provides a new > chronology for the human Y chromosome and reveals a deep phylogenetic > structure in Africa," by Rosaria Scozzari et al, Genome Research, Jan. > 2014. > > "This geographical confinement of deep lineages is at odds with the > mainly eastern African position of sites providing fossils of > comparable ages (McDougall et al. 2005, but see Tattersall and > Schwartz 2008). The question then becomes: when did these lineages > reach central-western Africa? Two hypotheses can be put forward: > first, ancient residence of A1b and A1a in eastern Africa, followed > by relocating to central-western Africa and extinction in the > motherland eastern Africa (possibly together with other yet unknown > deep rooted branches), or second, ancient residence of A1b and A1a > in central-western Africa, with loss of fossil record there. The > finding of the oldest lineage recorded so far (A00, 338 kya) in > Cameroon (Mendez et al. 2013), adds to our phylogeographic results > in suggesting centralwestern Africa as a broad region populated by > deep MSY lineages earlier than 160 kya." > > There may have been further interesting statements published since then, > but this is the best I can offer tonight! > > One factor that has not been mentioned much by studies of human > prehistory is that this area of Cameroon has been a refugium during > periods of harsh climate change, resulting in its becoming a > biodiversity hotspot, where today the rarest species of Chimpanzees and > Gorillas can be found, among other animals. > > Thus one scenario that could be explored is that humans, like these > other primates, could have ended up in Cameroon during one of the dry > periods when it provided a haven. If there were other branches dating to > the same or earlier period as A00, they could have been lost during > those adversities. > > Since the model that has been gaining the most prominence is the > "Braided Stream," with many small and diverse populations of early > humans in Africa repeatedly separating and re-joining, it would not be > as surprising that one region contributed the oldest Y lineages, while > another has the oldest mtDNA, or autosomal DNA. > > That being said, there is much that cries out to be studied right there > in Cameroon, which has some of the greatest ethnic diversity of any > country in the world. Due to limited funding, we currently have no > short-term plans to study the mtDNA of our samples, but I think it would > be a mistake to overlook that angle in the longer term. > > We are in conversations with Melissa Wilson Sayres, of Arizona State, > who hopes to be assisting us in analyzing the data we collect. She > thinks, and I agree, that autosomal studies of these Cameroonian > populations would be very important and interesting to do in the > future. But new samples, collected under a distinct protocol, would > have to be gathered for that project, so that we'd have even stronger > mechanisms in place to protect the privacy of the sample donors, because > of the far greater medical implications of autosomal variation. > > I would be surprised to hear of any larger concentration of A00 samples > being discovered in another country, but of course there are many > unstudied, remote or dangerous corners of Africa where very little is > known of the people's DNA, compared with the very thorough sampling of > European populations. > > Although I must say it is still hard for me to wrap my head around what > could have happened, I would guess that the relatively tiny number of > A00 living today suggests that a combination of genetic drift, and > perhaps warfare, or subjugation of indigenous peoples by more aggressive > warriors, with lack of ideal agricultural land and access to markets > creating difficult conditions for subsistence, must have kept A00 from > attaining a substantial population size, with isolation in the very > rugged and inaccessible mountains of Cameroon allowing them to just > barely hang on and survive over so many centuries and millennia. We > often see little pockets of rare genetic groups in small, high mountain > valleys, as some recent studies on the Caucasus have shown. > > I hope all who find this really interesting will stop to consider that > we are not able to fund our research out of our own pockets, as the cost > of testing hundreds of samples at even the most inexpensive prices > becomes very high. This can only be done if many people come together > to share the burden and make it light. We have so little time left > before our deadline. As soon as the Christmas festivities allow, I hope > a good number of our kind readers will stop by our website at > http://experiment.com/a00west, to support this project financially, > allowing us to pay our bills and gather more essential data, for the > benefit of all. > > Bonnie > > -- > *Farther Back We All Connect* > > > On 12/23/2015 9:41 PM, Andreas West wrote: > > Dear Bonnie, > > > > > > Thank you for keeping us informed about the progress. I've tried to > lookup information about the Bangwa on Wikipedia but couldn't find > anything. Only information available is on the Mbo, it's article mentions > the Bangwa but there is no standalone article. > > > > Maybe someone attached to the project would like to write it, especially > now from the Adam background. > > > > Just for my understanding. Is Cameroon now considered to be the birth > place of Adam or is that unlikely until a higher percentage of A00 samples > are found anywhere else in a location? > > > > As E1b1a is so much more present there does it mean that most A00 lines > unfortunately died out? > > > > Andreas > > ** > > ------------------------------- > To unsubscribe from the list, please send an email to > GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without > the quotes in the subject and the body of the message >

https://www.sciencenews.org/article/roosters-run-afoul-genetic-rules?tgt=nr

I remember seeing a show on Canadian TV many years ago (probably 30) where they went to a remote fishing village in Newfoundland and interviewed a chap whose ancestors came from St. Mullins in County Carlow Ireland. They also talked to residents of St. Mullins. The accent was the same & the expressions were the same even though many generations had passed since people from St. Mullins had immigrated to this remote Newfoundland fishing village. This always stuck in my mind as I have been to St. Mullins and my wife's grandparents are buried there. murray On Dec 19, 2015, at 6:19 AM, Paul Conroy via wrote: > Fascinating! The Irish population in Newfoundland is sourced from only a > couple of specific areas: > 1. Waterford, Wexford and Kilkenny in the Irish South East, mostly > 2. Cork in the Irish South, to a lesser extent > > Both my parents show some Newfoundland relatives from SE Ireland. At one > time many of these Irish people spoke Irish Gaelic (Gaeilge). In fact the > last speaker of the Leinster dialect of Irish Gaelic, died in St John's > some years ago. The dialect had died out in Ireland decades before that. > > Cheers, > Paul > > On Thursday, December 17, 2015, Ann Turner via <genealogy-dna@rootsweb.com> > wrote: > >> Genetic structure is detectable based on religious background in this study >> of Newfoundland and Labrador. That could be a consequence of marrying >> someone with the same religion, even though the general geographic >> background might not be that different. >> >> http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2015256a.html >> >> Genetic structure of the Newfoundland and Labrador population: founder >> effects modulate variability. >> >> Zhai G(1), Zhou J(2), Woods MO(1), Green JS(1), Parfrey P(2), Rahman P(2), >> Green RC(1). >> >> Author information: (1)Discipline of Genetics, Faculty of Medicine, >> Memorial University of Newfoundland, St John's, Newfoundland and Labrador, >> Canada. (2)Discipline of Medicine, Faculty of Medicine, Memorial >> University, St John's, Newfoundland and Labrador, Canada. >> >> The population of the province of Newfoundland and Labrador (NL) has been a >> resource for genetic studies because of its historical isolation and >> increased prevalence of several monogenic disorders. Controversy remains >> regarding the genetic substructure and the extent of genetic homogeneity, >> which have implications for disease gene mapping. Population substructure >> has been reported from other isolated populations such as Iceland, Finland >> and Sardinia. We undertook this study to further our understanding of the >> genetic architecture of the NL population. We enrolled 494 individuals >> randomly selected from NL. Genome-wide SNP data were analyzed together with >> that from 14 other populations including HapMap3, Ireland, Britain and >> Native American samples from the Human Genome Diversity Project. Using >> multidimensional scaling and admixture analysis, we observed that the >> genetic structure of the NL population resembles that of the British >> population but can be divided into three clusters that correspond to >> religious/ethnic origins: Protestant English, Roman Catholic Irish and >> North American aboriginals. We observed reduced heterozygosity and an >> increased inbreeding coefficient (mean=0.005), which corresponds to that >> expected in the offspring of third-cousin marriages. We also found that the >> NL population has a significantly higher number of runs of homozygosity >> (ROH) and longer lengths of ROH segments. These results are consistent with >> our understanding of the population history and indicate that the NL >> population may be ideal for identifying recessive variants for complex >> diseases that affect populations of European origin.European Journal of >> Human Genetics advance online publication, 16 December 2015; >> doi:10.1038/ejhg.2015.256. >> >> ------------------------------- >> To unsubscribe from the list, please send an email to >> GENEALOGY-DNA-request@rootsweb.com <javascript:;> with the word >> 'unsubscribe' without the quotes in the subject and the body of the message >> > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message >

No problem, I use Linux as well. I think you just interpreted the line above as a header, but it is really just another line in the table. The flood of SNP data is simply too much for human eyes :) Merry Christmas to you as well! Thomas On 12/23/2015 04:21 PM, Costa Tsirigakis wrote: > Hello Thomas, > > A browser ( Linux ) issue which i have sorted out now. > > You are correct it is Penso who is A457+ and I am aware of his positive result. > > He is my genetic cousin. > > My apologies to the list -- old age and poor eye sight ( sounds good as an excuse - lol ) > > Merry christmas to you all ! > > Regards, > > Costa > >> ---------------------------------------- >> From: Thomas Krahn via <genealogy-dna@rootsweb.com> >> Sent: Wed Dec 23 15:54:17 CET 2015 >> To: <genealogy-dna@rootsweb.com> >> Subject: Re: [DNA] Haplgroup J2_A457+_Observation >> >> >> Dear Costa, >> >> I think you're misinterpreting the table in the FTDNA project. It's not >> FTDNA kit 376161, but the one below (N16888) who shows the derived A457 >> allele. N16888 is J2-PF7392 and also PF7394+, PF7395+ like you. >> >> I suggest you compare every SNP between him and you to see if there are >> any differences. Also try to contact him and ask him for his personal >> SNPs from the BigY and compare them all. Let us know what you find. >> > ----------------------------------------------------- > Mail.be, WebMail and Virtual Office > http://www.mail.be

Dear Costa, I think you're misinterpreting the table in the FTDNA project. It's not FTDNA kit 376161, but the one below (N16888) who shows the derived A457 allele. N16888 is J2-PF7392 and also PF7394+, PF7395+ like you. I suggest you compare every SNP between him and you to see if there are any differences. Also try to contact him and ask him for his personal SNPs from the BigY and compare them all. Let us know what you find. Thomas On 12/23/2015 02:24 PM, Costa Tsirigakis via wrote: > Hello List, > > Just noticed, that kit # 376161 : is A457+ > > https://www.familytreedna.com/public/Y-DNA_J/default.aspx?section=ysnp > > The individual is also J-PF7344 + > > I am J- PF7395+ , A457+ > > A457+ background information : > > http://archiver.rootsweb.ancestry.com/th/read/GENEALOGY-DNA/2014-06/1402073036 > > Best regards, > > Costa..Tsirigakis > > -----------------------------------------------------Mail.be, WebMail and Virtual Officehttp://www.mail.be > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message

If it's nine generations it would also be an interesting case for small segment analysis. There's not much chance that all people identified triangulated on minimum 7cm and 700 SNP or the even more strict minimum criteria of FTDNA and AncestryDNA. Andreas > On 23 Dec 2015, at 09:33, Roberta Estes via <genealogy-dna@rootsweb.com> wrote: > > The irritating part is that the immigrant couple is not identified. What possible good could this be to anyone without that information? > > Roberta Estes > > -----Original Message----- > From: genealogy-dna-bounces@rootsweb.com [mailto:genealogy-dna-bounces@rootsweb.com] On Behalf Of steven perkins via > Sent: Tuesday, December 22, 2015 7:41 PM > To: genealogy-dna > Subject: [DNA] Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s > > http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005633 > > Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s > > Abstract: > > We recently discovered an inherited cancer syndrome caused by BRCA1-Associated Protein 1 (BAP1) germline mutations, with high incidence of mesothelioma, uveal melanoma and other cancers and very high penetrance by age 55. To identify families with the BAP1 cancer syndrome, we screened patients with family histories of multiple mesotheliomas and melanomas and/or multiple cancers. We identified four families that shared an identical BAP1mutation: they lived across the US and did not appear to be related. By combining family histories, molecular genetics, and genealogical approaches, we uncovered a BAP1 cancer syndrome kindred of > ~80,000 descendants with a core of 106 individuals, whose members descend from a couple born in Germany in the early 1700s who immigrated to North America. Their descendants spread throughout the country with mutation carriers affected by multiple malignancies. Our data show that, once a proband is identified, extended analyses of these kindreds, using genomic and genealogical studies to identify the most recent common ancestor, allow investigators to uncover additional branches of the family that may carry BAP1mutations. Using this knowledge, we have identified new branches of this family carrying BAP1 mutations. We have also implemented early-detection strategies that help identify cancers at early-stage, when they can be cured (melanomas) or are more susceptible to therapy (MM and other malignancies). > > Author Summary > Germline BAP1 mutations cause a cancer syndrome characterized by high incidence of mesothelioma (MM), uveal melanoma and other cancers, and by very high penetrance, as all individuals carrying BAP1 mutations developed at least one, and usually several, malignancies throughout their lives. > Through screening MM patients with histories of multiple cancers, we found four supposedly unrelated patients that shared an identical germline BAP1 mutation. We investigated whether this BAP1 mutation occurred in a ‘hot-spot’ for “de novo” mutations or whether these four MM patients shared a common ancestor. Using molecular genomics analyses we found that they are related. By genealogic studies we traced their ancestor to a couple that emigrated from Germany to North America in the early 1700’s; we traced the subsequent migration of their descendants, who are now living in at least three different US States. Our findings demonstrate that BAP1 mutations are transmitted among subsequent generations over the course of centuries. This knowledge and methodology is being used to identify additional branches of the family carrying BAP1 mutations. Our study shows that the application of modern genomic analyses, coupled with “classical” family histories collected by ! the treating physician, and with genealogical searches, offer a powerful strategy to identify high-risk germline BAP1 mutation carriers that will benefit from genetic counseling and early detection cancer screening. > > -- > Steven C. Perkins SCPerkins@gmail.com http://stevencperkins.com/ > Indigenous Peoples' Rights http://intelligent-internet.info/law/ipr2.html > Indigenous & Ethnic Minority Legal News http://iemlnews.blogspot.com/ Online Journal of Genetics and Genealogy http://jgg-online.blogspot.com/ S.C. Perkins' Genealogy Page http://stevencperkins.com/genealogy.html > S.C. Perkins' Genealogy Blog http://scpgen.blogspot.com/ > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message > > > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message

Hi Obed, What an interesting finding. Are you aware of this paper? "Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent" http://www.sciencemag.org/content/350/6262/820 Although I appreciate your thinking of our work, it seems just as likely to me that you have found traces of the Neandertal DNA that was included in the back-migration to Africa from the Mediterranean-Middle Eastern region, several thousand years ago. I hope we'll all continue to investigate and learn more about this question! Bonnie -- *Farther Back We All Connect*

Oh, this is sad. Obviously the Maya and Pima DNA they mention is found in those reference populations that are among the few samples of Native American DNA available for comparison. So almost any Native American will show some degree of either "Maya" or "Pima" ancestry. The press has gone wild with this, without understanding the situation. I wish someone would set them straight! Bonnie -- *Farther Back We All Connect*

Dear friends, Many of you remember the excitement and pride we felt when members of the genetic genealogy community played a leading role in the discovery of A00, the earliest branch of the Y-chromosome phylogenetic tree, when our paper was published in early 2013. There was an outpouring of support when we asked for donations in summer and fall 2013, for our proposed research project to collect more A00 samples in Cameroon. We were fully funded for our first trips by the community, with only modest effort. Then we found out how much we didn't know about getting through an ethical review process, but eventually, we found our way to the goal -- we were finally approved this past summer. Matthew immediately took to the field, and collected over 200 new samples among the ethnic groups known to have A00 among them, the Bangwa, and his own Mbo people. Testing by Thomas and Astrid Krahn at YSEQ revealed that 35 of these samples belong to A00, a much higher percentage than anticipated! Most of the non-A00 samples belong to haplogroup E1b1a, and a few belong to B2a1, A0, and other groups we have yet to determine. Now we're following through with the rest of the study, gathering samples from other areas of gradually increasing distance from the A00 epicenter, to find out the distribution and diversity of this super-rare group. Matthew made another trip in October, and collected as many samples again, from the Bamileke, and more outlying Bangwa. These now need to be tested, for 18 STRs in every sample, and two SNPs in each sample that has the distinctive A00 haplotype. This has shown, so far, that there are two main branches of A00, one found among the Bangwa, and the other among the Mbo. One man has been found who belongs to neither branch, and we'll be getting a full Y sequence of his DNA, to add his branch to our tree. We'll do the same for any other member of A00 we find who doesn't belong to one of these two branches, or who shows notable diversity in his haplotype. And of course, we'll be on the lookout for anyone who could possibly be a member of a brand-new haplogroup! To see the current branches of the A00 tree, please go to *http://tinyurl.com/o74vodu* On our next field trip, in January, Matthew will sample peoples to the West, the Banyang and Ejagham. Our exciting news is that Thomas Krahn will be traveling to Cameroon in January, and will accompany Matthew! They'll also visit villages previously sampled, to return results to the men already tested, something almost never done in traditional academic studies. We, as genetic genealogists, see them as individuals, not just sources of raw material. They are interested in learning about their paternal lineages, and we are trying to learn as much as possible about the A00-bearing families and their history. Does that sound like something you'd like to support? We're now in our crowdfunding phase again, after two years of not asking for any of your money. Our goal is to raise $7,655, and we've received $3,623 in donations from 41 donors so far, leaving us $4032 to go! We only have two weeks to make it to our goal by our deadline, Jan. 6th! Please help us reach it, at *http://experiment.com/A00west* Here are some examples of what your gift will buy: * For $25, you can buy three days of meals for Matthew in the field. * For $35, you can pay for the printing of all of our Informed Consent and Questionnaire forms that we use with each DNA donor. * For $42, you can pay for one day's transportation in the field. * For $50, you can pay for three days' lodging for Matthew in the field. * For $52, you can pay for about 10% of the SNP testing of the A00 samples that Matthew collected in October. * For $84, you can pay the salary of the driver or translator for the field trip. * For $105, you can pay for the SNP testing of 1/5 of the A00 samples. * For $132, you can pay for the SNP testing of 1/4 of the A00 samples. * For $175, you can pay for the SNP testing of 1/3 of the A00 samples, or the STR testing of about 5% of all the Bamileke & Bangwa samples from October's trip. * For $250, you can pay for the STR testing of 7% of all the samples. * For $350, you can pay for the STR testing of 10% of all the samples. * For $500, you can pay for the STR testing of 1/7 of all the samples. * For $525, you can pay for the SNP testing of all of the A00 samples from October. * For $700, you can pay for the STR testing of 1/5 of all the samples. * For $880, you can pay for the STR testing of 1/4 of all the samples. * For $1200, you can pay for the STR testing of over 1/3 of all the samples. * For $1760, you can pay for the STR testing of half of all the samples. * For $2000, you can pay for the STR testing of 57% of all the samples. * For $3520, you can pay for the STR testing of all the Bamileke and Bangwa samples collected in October. This year, inspiring people to donate has been a lot more challenging than the first time. We're now really doing what we promised to do back then, so please don't let us down! *http://experiment.com/A00west* is where you can contribute*. *There's much more yet to be done. After the trip to the West, we plan to sample the Pygmy peoples and their neighbors, to the South and East, where Matthew found a few A00 around the same time as he collected the original Mbo A00 samples (those samples now belong to the Center for Genetic Anthropology at University College London -- we have no access to them). And we plan more full Y sequences, as I've mentioned. We're doing cutting-edge, basic scientific research, which will contribute substantially to current efforts to ever more accurately date the TMRCA of the entire tree, and all the earliest nodes within it, as in the new paper by Barbieri et al, Refining the Y Chromosome Phylogeny with Southern African Sequences -- see http://biorxiv.org/content/early/2015/12/20/034983 But they didn't perform full Y sequences of their samples, as we've done with our existing A00 sample from the Perry family, and will be doing with others. All of these sequences will be available for public access, as will the Y-STR haplotypes. Please help this research prosper and come to a successful conclusion, with your generous donation at *http://experiment.com/A00west* Donors are entitled to advance access to our data! Just let us know you're interested. Wishing you a joyful holiday season, Bonnie Schrack for the A00 Cameroon Research Project http://www.facebook.com/A00.Cameroon.Project/ http://haplogroup-a.com -- *Farther Back We All Connect*

David, Haven't seen a reply go past so although I'm not Jim. Log in to GEDMatch Click on the _*EDIT or DELETE your DNA resource profiles. *_link below your list of kits Select the one you want to remove from the public matching system and click Edit There's an option on that page where kits can be marked as Public, Private or Research Public / Private / Research: (Research kits can be used with any GEDmatch utility, but they will not be shown in comparison results for other kits. We do NOT encourage the use of the 'Research' option with normal kit uploads, since it is not consistent with the free exchange of genealogy information.) Public Private Research Very useful to mark what are essentially the same kit as Research, leaving just one of them pubic, eg if you've uploaded your kits from all 3 companies, or as you've been doing, manipulating the no calls etc, the rest are all still available to you as Research kits. Lorna Henderson http://LornaHen.com On 23/12/15 02:28, David Hamill via wrote: > Jim, could you share some details about how to go about uploading and notifying GEDmatch about research kits? I have some plans along these lines and am glad they have a way of handling them that won’t cause confusion for others. > > Thanks > David > >> On Dec 22, 2015, at 3:00 AM, genealogy-dna-request@rootsweb.com wrote: >> >> No trouble. GEDmatch has a provision for research kits - it's important to notify them, so those kits don't gum up the works. The final kit can then be used for comparisons. The GEDmatch Admins have found, and removed, a few bogus kits from time to time. >> >> Jim - www.segmentology.org > > > ------------------------------- > To unsubscribe from the list, please send an email to GENEALOGY-DNA-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message