Transcribed by Diane Moore. Geo. THE CARLISLE PATRIOT - Saturday, July 22, 1843 ISTHMUS OF PANAMA.--At a meeting of the Academy of Sciences at Paris of Wednesday week, M. AGAGO made a communication of the steps that have been taken towards the great work of the cutting through the Isthmus of Panama, which has been so long talked of, but which many persons have regarded as chimerical. According to this communication, a contract has been entered into by Messrs. BARING and Co., of London, with the Republic of New Grenada, in virtue of which the republic is to cede to them the line required for the projected canal, with 80,000 acres of land on the two banks, and 400,000 acres in the interior of the country. Messrs. BARING and Co. had, it is said, in the first instance, fixed the amount of toll for the navigation of the canal at the exorbitant price of 18f. per ton, but they have reduced it to 8f. The work, upon which from 4,000 to 5,000 men are to be engaged, is to be completed in five years.