Haemophilia is a sex linked disease and is therefore carried on the X Chromosome. A male only has one X chromosome (the other part of the pair being the Y chromosome) and therefore will show the signs of the disease if he carries the gene. A female has two X chromosomes and can carry the gene on one of the X chromosomes without showing any signs of the disease. If a female has the gene on both her X chromosomes then she will also show signs of the disease. A son inherits his X chromosome from his mother not the father. The father will pass his Y chromosome to his sons and his X chromosome to his daughters. Therefore the sons of George who got haemophilia would have inherited it from their Mother as she would have passed on her X chromosome with the haemophilia gene. Hope this is of help. Jeff ----- Original Message ----- From: "Sandra J Smith" <sandra.s@ntlworld.com> To: <eng-buckinghamshire@rootsweb.com> Sent: Sunday, March 30, 2008 10:12 PM Subject: [ENG-Buck] Haemophilia in Aston Clinton > This is a real long-shot in an attempt to discover the father of an > illegitimate child..... > > George Foskett, the illegitimate son of Charlotte Foskett, was born in > Aston Clinton in 1845. > I have just discovered that four of George's son's died as a result of > haemophilia (uncontrolled bleeding). I believe that this disease is > passed down the male line, so George's father was probably a carrier. > Have any other lister's discovered haemophilia in any other Aston Clinton > family? > > Regards > Sandra > _____________________________________________ > > Have you considered adding "postems" to "your" events on > www.freebmd.org.uk , giving your contact details? Other researchers will > then be able to make contact. Click on the info button to add your postem. > ------------------------------- > To unsubscribe from the list, please send an email to > ENG-BUCKINGHAMSHIRE-request@rootsweb.com with the word 'unsubscribe' > without the quotes in the subject and the body of the message