David, I have just read Marilyn Larach's excellent article, on which you were science advisor. sciencecases.lib.buffalo.edu/cs/files/ Anesthesia_Breakthroughs_bioscience.pdf I am totally in awe of your accomplishment that underlines the benefits continuing to stream from our increasing understanding of the human genome. I trust that the broader commitments apparent in the M222 community will help identify the family occurrence of the mutation in chromosome 19 that is responsible for malignant hyperthermia in Canadian and Irish families. Best, Malcolm On 31 Oct 2013, at 02:21, David Maclennan wrote: > Sandy, there is a difference between a Royal Society University > Research > Fellow, which Jim Wilson is, and a Fellow of the Royal Society - > Fellows > of the Royal Society get to add FRS behind their names. > > David H MacLennan FRS > > On 2013-10-30 8:44 AM, "Alexander Paterson" > <[email protected]> wrote: > >> Hi Paul, >> >> They are not equivalent. It was my whole genome that led to the >> discovery >> of >> 11 new SNPs downstream of M222+. Another Scotsman's whole genome >> led to >> the >> discovery of 13 new SNPs downstream of M222. >> >> This information comes from Jim Wilson, a PhD and a Fellow of the >> Royal >> Society. >> >> Best, >> >> Sandy >> >> -----Original Message----- >> From: [email protected] >> [mailto:[email protected]] On Behalf Of Paul Ó Du??aig >> Sent: 30 October 2013 09:16 >> To: [email protected] >> Subject: Re: [R-M222] Chromo2 order ?? >> >> Phylogenetically they are "equivalent", this is the term used by >> ISOGG for >> two or more separate SNP's that mark the one branch. Basically >> until a >> S661+/S658- or a S658+/S661- man is found the two are regarded as >> functionally equivalent for purposes of the haplogroup tree. As an >> example, >> DF41 is equivalent to CTS2501, all DF41+ men tested so far have >> come back >> as CTS2501+, likewise all CTS2501+ men we have found (through Geno >> 2.0 >> testing) have likewise tested as DF41+. The two are indeed separate >> SNP's >> but are regarded "equivalent" when it comes to defining: >> *R1b1a2a1a2c1i* >> >> L21 has a similar position with regards to L459 and Z290. Going by >> what we >> know from Chromo2 it would seem that there are at least 24 snp's >> "equivalent to" M222. >> >>> From my original email, I should have put DF85 in Parentheses eg. >>> "S673 >> (DF85)" -- DF85 been just a different name for the same SNP. Just >> like how >> ScotlandsDNA call DF41: S524 -- same SNP just different name. >> >> As you note in case of S661/S658 and S660/S659 they are indeed >> 4 separate snp's, but they only mark two levels in the phylogeny. Of >> course >> if enough people do Chromo2 tests we may end up separating each of >> these >> from each other. >> >> -Paul >> (DF41+) >> >> >> On Wed, Oct 30, 2013 at 6:41 AM, Alexander Paterson < >> [email protected]> wrote: >> >>> Hi Paul, >>> >>> Just a clarification. >>> >>> >>> S661 >>> S658 >>> S660 >>> S659 >>> S588 >>> S7814 >>> S603 >>> S595 >>> S592 >>> S673/DF85 (you are probably negative for this one) >>> S668 (you are probably negative for this as it's subclade of DF85) >>> S568 >>> S567 >>> >>> S661 is not equivalent to S658. >>> S660 is not equivalent to S659. >>> >>> They are four separate mutations downstream of M222. >>> >>> There are a total of 27 SNPs downstream of M222. I alone have 11 >>> SNPs >>> downstream of M222. >>> A Scotsman has 13 SNPs downstream of M222. >>> There are three more. >>> >>> All 27 were discovered by ScotlandsDNA. >>> >>> Best, >>> >>> Sandy >>> >>> >>> -----Original Message----- >>> From: [email protected] >>> [mailto:[email protected]] On Behalf Of Paul Ó Du??aig >>> Sent: 29 October 2013 16:07 >>> To: Helen Murphy; [email protected] >>> Subject: Re: [R-M222] Chromo2 order ?? >>> >>> Helen, >>> >>> Chromo2 is a chip based test from ScotlandsDNA/IrelandsDNA/ >>> EnglandsDNA. >>> They've included several SNP's that help sub-divide M222. One of >>> these >>> SNP's is DF85 which you probably have seen talk about on the list. >>> From >>> looking at your matches in the Ireland project it's probable that >>> your >>> husband is DF85-. >>> >>> The advantage for you in taking a Chromo2 test is that it would >>> test you >>> for the following SNP's under M222: >>> S661/S658 >>> S660/S659 >>> S588 >>> S7814 >>> S603 >>> S595 >>> S592 >>> S673/DF85 (you are probably negative for this one) >>> S668 (you are probably negative for this as it's subclade of DF85) >>> S568 >>> S567 >>> >>> Here's a phylogenetic tree that shows the current known structure of >>> these >>> SNP's under M222: (maintained by Iain Kennedy) >>> http://www.kennedydna.com/M222.pdf >>> >>> If you come back positive on any of those SNP's it would at least >>> "tie" >>> your husband down to a particular part of wider M222 "tree". >>> >>> Regards >>> -Paul >>> (DF41+) >>> >>> >>> On Tue, Oct 29, 2013 at 3:03 PM, Helen Murphy <[email protected]> >>> wrote: >>> >>>> I administer my husband Dave Murphy kit #201315 at ftDNA - he is >>> R-M222 >> - >>>> I have done his markers up to 111 & his autosomal at Family Finder. >>> What >>> is >>>> Chromo2 ? and should I order it for him? He is full Irish, his >>>> grand >>>> parents & gr-gr came from Galway, Mayo, Cork, & Waterford. Please >>> advise... >>>> >>>> Helen Murphy - [email protected] >>>> >>>> PS: I am #128128 on ftDNA - with Reynolds line in Virginia >>>> >>>> ------------------------------- >>>> To unsubscribe from the list, please send an email to >>>> [email protected] with the word 'unsubscribe' without >>> the >>>> quotes in the subject and the body of the message >>>> >>> >>> ------------------------------- >>> To unsubscribe from the list, please send an email to >>> [email protected] with the word 'unsubscribe' >>> without the >>> quotes in the subject and the body of the message >>> >>> >>> >>> ------------------------------- >>> To unsubscribe from the list, please send an email to >>> [email protected] with the word 'unsubscribe' >>> without the >>> quotes in the subject and the body of the message >>> >> >> ------------------------------- >> To unsubscribe from the list, please send an email to >> [email protected] with the word 'unsubscribe' without >> the >> quotes in the subject and the body of the message >> >> >> >> ------------------------------- >> To unsubscribe from the list, please send an email to >> [email protected] with the word 'unsubscribe' without >> the >> quotes in the subject and the body of the message > > > > ------------------------------- > To unsubscribe from the list, please send an email to [email protected] > with the word 'unsubscribe' without the quotes in the subject and > the body of the message