Sorry, Sandy -- I was not sufficiently specific. I wanted to see what a change in a marker did to the RCC after that one change. I wanted to take the simplest possible case -- how a marker change affected a starting haplotype. Think of the starting haplotype as being that of a progenitor, and you want to see how a change of one in any marker would affect the RCC of the pair (progenitor vs descendant with that one marker change). I picked an arbitrary R1b haplotype string -- I think I took a Hamilton string as the progenitor. It could be any string as long as it is representative of a real case. Then I investigated what would happen to the value of RCC between the progenitors 'starter' string and EACH of the ones that I chose to change. I changed both low and high markers; I changed by one, to four markers. I changed combinations, too. I ran the RCC determination for each example. This was done four and a half years ago. Here is the result: Markers 1Min 1Max 1Min+1Max 2Min 2Max 2Min+2Max 37 2.85 2.02 4.46 11.49 7.87 17.76 /n changes 2.85 2.02 2.23 5.74 3.94 4.11 I changed one small number by one — column 2 I changed one large number by one — column 3 I changed one small and one large number by one — column 4 I changed two small numbers by one — column 5 I changed two large numbers by one — column 6 I changed two small numbers and two large numbers by one — column 7 The results are given in row 2. After dividing by the number of changes made, you have the results in row 3 You will note that my contention (that you quoted below) is quite correct. Namely, that a change of 1 in GD can cause a change in RCC of about 3, depending on which marker (low vs high) is changed…. In fact, that is a conservative statement since the real result was 2.02 in one case and 2.85 in the other. Q.E.D. - Bye from Bill Howard On Jul 11, 2011, at 1:18 PM, Sandy Paterson wrote: > And this statement? > > > <Finally, about the association of genetic distance (GD) with RCC -- I have > run many strings of haplotypes and have changed various marker values by 1, > 2, 3, and compared many sets with each other. They show that a change of 1 > in GD can cause a change in RCC of about 3, depending on which marker (low > vs high) is changed....> > > > A change in GD of 1 can be as high as 16? Maybe even higher? > > > Sandy > > > > -----Original Message----- > From: dna-r1b1c7-bounces@rootsweb.com > [mailto:dna-r1b1c7-bounces@rootsweb.com] On Behalf Of Bill Howard > Sent: 11 July 2011 14:46 > To: dna-r1b1c7@rootsweb.com > Subject: Re: [R-M222] M222 Tree > > To the list: > > Yes, Sandy has done the calculation right. > > R1b1c7 Research and Links: > > http://clanmaclochlainn.com/R1b1c7/ > ------------------------------- > To unsubscribe from the list, please send an email to DNA-R1B1C7-request@rootsweb.com with the word 'unsubscribe' without the quotes in the subject and the body of the message