FYI... ----Original Message Follows---- From: [email protected] Reply-To: [email protected] To: [email protected] Subject: Re: SNP discovery [was Re: [DNA] Cohen Modal Haplotype and J2] Date: Thu, 17 Mar 2005 07:03:54 +0000 Thanks to the very astute observation of an as yet to be named Lister, we have decided to use some of the monies from our product sales to establish a R&D programe to, in this case, explore one definite new R1b SNP, and others that may have promise (but may turn out to be private SNPs). As I have said before this List has an incredible range of talent within the ranks. A well known researcher (not sure I can mention their name) is writing a book including a principle components analysis, mining in a couple of databases, but what comes out the hopper will probably pale in comparison to what our listers have done in relation to haplogroups I and R1b. David F. -------------- Original message -------------- > In a message dated 03/16/05 10:49:35 AM Pacific Standard Time, > [email protected] writes: > > > Furthermore, little to nothing has been reported on J1 > > sub-clades. > > It may be harder than we expected to discover new SNPs, the basis for > defining subclades. Last fall I reported on the Samaritan study, which netted > only > one new SNP per 154,000 bases screened. > > http://archiver.rootsweb.com/th/read/GENEALOGY-DNA/2004-09/1094185143 > > I remained somewhat hopeful that SNPs would be easier to discover in broader > population samples. But... the recent Perlegen study lists one SNP per 67,000 > bases, with populations about as divergent as you can get: European Americans, > African Americans, and Han Chinese. That's better, but still discouraging. > Many of these were singletons (occurring in only one sample), so we can't really > tell if they were "private" SNPs or ones that would be worth screening for. > > http://archiver.rootsweb.com/th/read/GENEALOGY-DNA/2005-02/1109191392 > > We may have to wait for the day of the "$1000 genome," when it becomes > practical to actually sequence large sections of the Y chromosome. > > Ann Turner - GENEALOGY-DNA List Administrator > Search or Browse the archives, Subscribe or Unsubscribe at > http://lists.rootsweb.com/index/other/DNA/GENEALOGY-DNA.html > > > > > > ============================== > New! Family Tree Maker 2005. Build your tree and search for your ancestors at > the same time. Share your tree with family and friends. Learn more: > http://landing.ancestry.com/familytreemaker/2005/tour.aspx?sourceid=14599&target > id=5429 > ============================== Census images 1901, 1891, 1881 and 1871, plus so much more. Ancestry.com's United Kingdom & Ireland Collection. Learn more: http://www.ancestry.com/s13968/rd.ashx