This is a Message Board Post that is gatewayed to this mailing list. Classification: Query Message Board URL: http://boards.ancestry.com/mbexec/msg/rw/0V.2ADE/2343.2.1 Message Board Post: I know this off suject of genealogy but in is an illness taht can be passed down genetically What is amyloidosis? Amyloidosis is a group of diseases that result from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area, and may not be harmful or only affect a single tissue of the body. This form of amyloidosis is called localized amyloidosis. Amyloidosis that affects tissues throughout the body is referred to as systemic amyloidosis. Systemic amyloidosis can cause serious changes in virtually any organ of the body. Amyloidosis can occur as its own entity or "secondarily" as a result of another illness, including multiple myeloma, chronic infections (such as tuberculosis or osteomyelitis), or chronic inflammatory diseases (such as rheumatoid arthritis and ankylosing spondylitis). Amyloidosis can also be localized to a specific body area from aging. This localized form of amyloidosis does not have systemic implications for the rest of the body. The protein that deposits in the brain of patients with Alzheimer's disease is a form of amyloid. Systemic amyloidosis has been classified into three major types that are very different from each other. These are distinguished by a two-letter code that begins with an A (for amyloid). The second letter of the code stands for the protein that accumulates in the tissues in that particular type of amyloidosis. The three types of systemic amyloidosis are primary (AL), secondary (AA), and hereditary (ATTR). Primary Amyloidosis Primary amyloidosis, or AL, is occurs when a specialized cell in the bone marrow (plasma cell) spontaneously overproduces a particular protein portion of an antibody called the light chain. (This is why it is coded as AL). The deposits in the tissues of persons with primary amyloidosis are AL proteins. Primary amyloidosis can occur with a bone marrow cancer of plasma cells called multiple myeloma. Primary amyloid is not associated with any other diseases, but is a disease entity of its own, usually requiring chemotherapy treatment. Secondary Amyloidosis When amyloidosis occurs "secondarily" as a result of another illness, such as multiple myeloma, chronic infections (e.g., tuberculosis or osteomyelitis), or chronic inflammatory diseases (e.g., rheumatoid arthritis and ankylosing spondylitis), the condition is referred to as secondary amyloidosis, or AA. The amyloid tissue deposits in secondary amyloidosis are AA proteins. The treatment of patients secondary amyloidosis is directed at treating the underlying illness in that particular patient. Familial Amyloidosis Familial amyloidosis, or ATTR, is a rare form of inherited amyloidosis. The amyloid deposits in familial amyloidosis are composed of the protein transthyretin, or TTR, which is made in the liver. Familial amyloidosis is inherited an autosomal dominant in genetics terminology. This means that for the offspring of a person with the condition, there is a 50% chance of inheriting it. 1 2 Glossary Amyloidosis Center | Next