Found this on a Michigan list a while back, thought it might be useful if ancestors died in these places/years: Year(s) / Region, Area, City or State / Disease 1657 / Boston / Measles 1687 / Boston / Measles 1690 / New York / Yellow Fever 1713 / Boston / Measles 1729 / Boston / Measles 1732-1733 / Worldwide / Influenza 1738 / South Carolina / Smallpox 1739-1740 / Boston / Measles 1747 / Connecticut, New York, Pennsylvania, South Carolina / Smallpox 1759 / North America / Measles 1761 / North America and West Indies / Influenza 1772 / North America / Measles 1775 / North America (especially in North East) / Unknown 1775-1776 / Worldwide / Influenza 1783 / Dover, Delaware (was extremely fatal) / Bilious Disorder 1788 / Philadelphia and New York / Measles 1793 / Vermont / (a "putrid" fever) and Influenza 1793 / Virginia (killed 500 in 5 counties in 4 weeks) / Influenza 1793 / Philadelphia / Yellow Fever 1793 / Harrisburg, PA (many unexplained deaths) / Unknown 1793 / Middletown, Pennsylvania (many mysterious deaths) / Unknown 1794 / Philadelphia, Pennsylvania / Yellow Fever 1796-1797 / Philadelphia, Pennsylvania / Yellow Fever 1798 / Philadelphia, Pennsylvania (one of the worst) / Yellow Fever 1803 / New York / Yellow Fever 1820-1823 / Nationwide (started at Schuylkill River & spread) / "Fever" 1831-1832 / Nationwide (brought in by English Immigrants) / Asiatic Cholera 1832 / New York and other major cities / Cholera 1833 / Columbus, Ohio / Cholera 1833-34 / Kentucky / Cholera 1834 / New York City, New York / Cholera 1837 / Philadelphia / Typhus 1841 / Nationwide (especially severe in the South) / Yellow Fever 1847 / New Orleans / Yellow Fever 1847-1848 / Worldwide / Influenza 1848-1849 / North America / Cholera 1849 / New York / Cholera 1850 / Nationwide / Yellow Fever 1850-1851 / North America / Influenza 1851 / Coles County, Illinois, The Great Plains, and Missouri / Cholera 1852 / Nationwide (New Orleans 8,000 died that summer) / Yellow Fever 1855 / Nationwide / Yellow Fever 1857-1859 / Worldwide (one of the largest epidemics) / Influenza 1860-1861 / Pennsylvania / Smallpox 1865-1873 / Philadelphia, New York, Boston, New Orleans, Baltimore, Memphis, Washington DC / A series of recurring epidemics of Smallpox, Cholera, Typhus, Typhoid, Scarlet Fever, Yellow Fever, and Influenza 1873-1875 / North America & Europe / Influenza 1878 / New Orleans (last great epidemic) / Yellow Fever 1885 / Plymouth, Pennsylvania / Typhoid 1886 / Jacksonville, Florida / Yellow Fever 1918 / Worldwide (high point year) more people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps. / Influenza or Spanish Flu